Inclusion Criteria:

Dose-escalation part:

- Primary or secondary acute myeloid leukaemia, including subjects:

with first or subsequent relapse after standard therapy, with no established treatment
options; refractory to available therapies, e.g. who failed to achieve complete remission
after chemotherapies; Newly-diagnosed elderly subjects (over 60 years) according to WHO
classification (≥20 blasts in bone marrow), who did not accept or were not eligible for
chemotherapy (first line therapy)

- Subjects with myelodysplastic syndrome (IPSS Int-2 or high risk) resistant or
intolerant to standard treatment and not candidates for allogeneic HSCT.

- Subjects with chronic myeloid leukaemia in chronic, accelerated or blast-phase,
resistant or intolerant to standard treatment and not candidates for allogeneic HSCT.

- Subjects with myeloproliferative disorders and no effective treatment options.

- Subjects with acute lymphoblastic leukaemia, relapsing, resistant or intolerant to
standard treatment and no effective treatment options.

- Subjects with chronic lymphocytic leukaemia, relapsing, resistant or intolerant to
standard treatment and no effective treatment options.

- Subjects with non-Hodgkin lymphoma, relapsing, resistant or intolerant to standard
treatment with no effective treatment options.

Cohort expansion part

- Primary or secondary acute myeloid leukaemia not eligible for chemotherapy (first
line therapy), including subjects

with first or subsequent relapse after standard therapy, for whom no established treatment
options are available; refractory to available therapies, e.g. who failed to achieve
complete remission after chemotherapies; Newly-diagnosed elderly subjects (over 60 years)
according to WHO classification (≥ 20 blasts in bone marrow), who did not accept or were
not eligible for chemotherapy (first line therapy)

- Subjects with chronic myeloid leukaemia in chronic or accelerated phase, resistant
or intolerant to standard treatment, who have not achieved a complete haematological
response, and are not candidates for allogeneic HSCT.

- Subjects with myeloproliferative disorders with no effective treatment options.

- Subjects with Philadelphia chromosome positive acute leukaemias including acute
lymphoblastic leukaemia and blast phase chronic myeloid leukaemia, relapsing,
resistant or intolerant to standard treatment with no effective treatment options.

Exclusion Criteria:

- Acute promyelocytic leukaemia.

- Ongoing uncontrolled bacterial, viral, fungal or atypical mycobacterial infection.

- Hyperleukocytosis with >50x10(9)/L leukaemic blasts.

- Chemotherapy, immunotherapy, biologic therapy or any experimental anti-cancer therapy
within 28days prior to study Day1 and/or not having recovered from its toxicity.

- Extensive radiotherapy involving ≥30% of bone marrow (e.g. whole pelvis, half spine)
within 6months prior to study Day1.

- Active CNS disease involvement.

- Any condition, including laboratory, medical history or pre-study assessment
findings, that in the opinion of the Investigator, constitute a risk or
contraindication for participation or that could interfere with the study
objectives, conduct or evaluation of a drug to be taken orally.

- Clinically relevant cardiac abnormalities or clinically relevant abnormalities .

- Known infection with human immunodeficiency virus, active hepatitis B, or hepatitis
C.

- Signs and symptoms suggestive of transmissible spongiform encephalopathy.

- Major surgery within 2weeks prior to study Day1.

- Haemoglobin <8g/dL at screening (can be transfused).

- Refractory to platelet transfusion (defined as increase of <20.109/L platelets 1hour
after transfusion).

- Coexistent second malignancy or history of prior malignancy within previous 3years
(excluding basal or squamous cell carcinoma of the skin, and in situ carcinoma of the
cervix that has been treated curatively).