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A Phase I, Dose-escalation Study of AS703569 Given Orally to Subjects With Haematological Malignancies


Phase 1
18 Years
N/A
Not Enrolling
Both
Haematological Malignancies

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Trial Information

A Phase I, Dose-escalation Study of AS703569 Given Orally to Subjects With Haematological Malignancies


The goal of this research study is to investigate for the first time the safety and
tolerability of a new drug (AS703569), called an aurora kinase inhibitor, being tested to
treat blood cancers in patients with different blood cancers. The research study will also
assess how the body breaks down AS703569 and what changes occur in the blood after oral
doses of AS703569. It will also look to see if there is any improvement in your blood
cancer. The use of AS703569 in this study is experimental.


Inclusion Criteria:



Dose-escalation part:

- Primary or secondary acute myeloid leukaemia, including subjects:

with first or subsequent relapse after standard therapy, with no established treatment
options; refractory to available therapies, e.g. who failed to achieve complete remission
after chemotherapies; Newly-diagnosed elderly subjects (over 60 years) according to WHO
classification (≥20 blasts in bone marrow), who did not accept or were not eligible for
chemotherapy (first line therapy)

- Subjects with myelodysplastic syndrome (IPSS Int-2 or high risk) resistant or
intolerant to standard treatment and not candidates for allogeneic HSCT.

- Subjects with chronic myeloid leukaemia in chronic, accelerated or blast-phase,
resistant or intolerant to standard treatment and not candidates for allogeneic HSCT.

- Subjects with myeloproliferative disorders and no effective treatment options.

- Subjects with acute lymphoblastic leukaemia, relapsing, resistant or intolerant to
standard treatment and no effective treatment options.

- Subjects with chronic lymphocytic leukaemia, relapsing, resistant or intolerant to
standard treatment and no effective treatment options.

- Subjects with non-Hodgkin lymphoma, relapsing, resistant or intolerant to standard
treatment with no effective treatment options.

Cohort expansion part

- Primary or secondary acute myeloid leukaemia not eligible for chemotherapy (first
line therapy), including subjects

with first or subsequent relapse after standard therapy, for whom no established treatment
options are available; refractory to available therapies, e.g. who failed to achieve
complete remission after chemotherapies; Newly-diagnosed elderly subjects (over 60 years)
according to WHO classification (≥ 20 blasts in bone marrow), who did not accept or were
not eligible for chemotherapy (first line therapy)

- Subjects with chronic myeloid leukaemia in chronic or accelerated phase, resistant
or intolerant to standard treatment, who have not achieved a complete haematological
response, and are not candidates for allogeneic HSCT.

- Subjects with myeloproliferative disorders with no effective treatment options.

- Subjects with Philadelphia chromosome positive acute leukaemias including acute
lymphoblastic leukaemia and blast phase chronic myeloid leukaemia, relapsing,
resistant or intolerant to standard treatment with no effective treatment options.

Exclusion Criteria:

- Acute promyelocytic leukaemia.

- Ongoing uncontrolled bacterial, viral, fungal or atypical mycobacterial infection.

- Hyperleukocytosis with >50x10(9)/L leukaemic blasts.

- Chemotherapy, immunotherapy, biologic therapy or any experimental anti-cancer therapy
within 28days prior to study Day1 and/or not having recovered from its toxicity.

- Extensive radiotherapy involving ≥30% of bone marrow (e.g. whole pelvis, half spine)
within 6months prior to study Day1.

- Active CNS disease involvement.

- Any condition, including laboratory, medical history or pre-study assessment
findings, that in the opinion of the Investigator, constitute a risk or
contraindication for participation or that could interfere with the study
objectives, conduct or evaluation of a drug to be taken orally.

- Clinically relevant cardiac abnormalities or clinically relevant abnormalities .

- Known infection with human immunodeficiency virus, active hepatitis B, or hepatitis
C.

- Signs and symptoms suggestive of transmissible spongiform encephalopathy.

- Major surgery within 2weeks prior to study Day1.

- Haemoglobin <8g/dL at screening (can be transfused).

- Refractory to platelet transfusion (defined as increase of <20.109/L platelets 1hour
after transfusion).

- Coexistent second malignancy or history of prior malignancy within previous 3years
(excluding basal or squamous cell carcinoma of the skin, and in situ carcinoma of the
cervix that has been treated curatively).

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Dose-Limiting Toxicity (DLT)

Outcome Description:

Dose-escalation part - The number of subjects experiencing at least a Dose-Limiting Toxicity (DLT), judged to be related to the study medication, evaluated over the first cycle only for each dose level and regimen, independently.

Outcome Time Frame:

21 days or 1 cycle

Safety Issue:

No

Principal Investigator

Narmyn Rejeb, M.D.

Investigator Role:

Study Director

Investigator Affiliation:

Merck Serono S.A., Geneva

Authority:

Switzerland: Ethikkommission

Study ID:

27335

NCT ID:

NCT01080664

Start Date:

December 2006

Completion Date:

August 2011

Related Keywords:

  • Haematological Malignancies
  • AS703569
  • Aurora Kinase Inhibitor
  • Haematological malignancies
  • Neoplasms
  • Hematologic Neoplasms

Name

Location

CTRC at the UT Health Science Center at San AntonioSan Antonio, Texas  78229