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The Risk of Esophageal Cancer in Relation to the Treatment and Prevention of Osteoporosis in Women

55 Years
Not Enrolling
Esophageal Cancer, Squamous Cell Carcinoma, Adenocarcinoma

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Trial Information

The Risk of Esophageal Cancer in Relation to the Treatment and Prevention of Osteoporosis in Women

Inclusion Criteria:

- Cases:

- Women in the database aged 55 or older between 1996 and 2008 with diagnosis of
esophageal cancer

- Comparator Controls:

- Each case was matched to all women in the random subcohort of 25,000 who had the
same year of birth as the case and were in the database at the time of

Exclusion Criteria:

- Women with diagnosis of any other cancer or Paget's Disease or who have received oral
or intravenous steroids before the index date

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Percentage of Participants With Exposure to Study Drugs (Case-Cohort Analysis)

Outcome Description:

To determine the use of study drugs (alendronate, etidronate, ibandronate, risedronate, and raloxifene) among female participants with esophageal cancer (cases) and a comparison subcohort, a case-cohort analysis was performed using women meeting criteria from the General Practice Research Database (GPRD, United Kingdom). Exposure to osteoporosis drugs administered 720 days before cancer onset was determined in cases and compared to contemporaneous assessments in a comparison subcohort matched by year of birth and membership in the GPRD on the case's onset date. Cases were confirmed and case onset dates determined by electronic algorithm (based on electronic medical record data) or by medical record review.

Outcome Time Frame:

Exposure to study drug at least 720 days before disease onset

Safety Issue:


Principal Investigator

Alec Walker, MD, DrPH

Investigator Role:

Study Director

Investigator Affiliation:

World Health Information Science Consultants, LLC


United States: Institutional Review Board

Study ID:




Start Date:

February 2010

Completion Date:

February 2012

Related Keywords:

  • Esophageal Cancer
  • Squamous Cell Carcinoma
  • Adenocarcinoma
  • Adenocarcinoma
  • Adenocarcinoma, Mucinous
  • Carcinoma
  • Carcinoma, Squamous Cell
  • Esophageal Diseases
  • Esophageal Neoplasms
  • Osteoporosis