Inclusion Criteria:

- adult patients, >=70 years of age;

- inoperable, locally advanced, metastatic non-squamous non-small cell lung cancer;

- >=1 measurable lesion;

- ECOG performance status 0-1.

Exclusion Criteria:

- neoadjuvant/adjuvant chemotherapy within 6 months prior to enrollment;

- radical radiotherapy with curative intent within 28 days prior to enrollment;

- history of >=grade 2 hemoptysis in 3 months prior to enrollment;

- evidence of CNS metastases;

- current or recent (within 10 days of first dose of Avastin)use of aspirin (>325
mg/day)or full dose anticoagulants or thrombolytic agents for therapeutic purposes.