Detection of Donor-Derived DNA in Semen Samples Among Recipients of Allogeneic Hematopoietic Stem-Cell Transplants
- To examine semen samples from male survivors of allogeneic hematopoietic stem cell
transplantation for the presence of donor-derived DNA.
OUTLINE: Semen samples are collected and assessed by flow cytometry and PCR. DNA samples are
compared to previously analyzed DNA extracted from survivor and donor. Samples are also
analyzed for sperm concentration, motility, morphology, and viability.
Observational Model: Case-Only, Time Perspective: Prospective
Presence of donor-derived DNA in semen samples of male survivors of allogeneic hematopoietic stem cell transplantation
end of study
Haydar A. Frangoul, MD
Vanderbilt-Ingram Cancer Center
United States: Federal Government
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|