Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
N/A
18 Years
85 Years
18 Years
85 Years
Open (Enrolling)
Both
Colorectal Cancer
Both
Colorectal Cancer
Trial Information
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
Inclusion Criteria:
- Referred for endoscopy at participating centre
Exclusion Criteria:
- Age <16 or >85
- Familial polyposis syndrome
- Lynch syndrome
- Known colorectal tumour
- Previous colorectal resection
- Pregnancy
- Chemotherapy in last 6 months
- Therapy with aspirin/other nonsteroidal anti-inflammatory drug (NSAID)
- Other immunosuppressive medication
- Incomplete left sided examination
- Colorectal carcinoma found at endoscopy
- Iatrogenic perforation at endoscopy
- Colorectal cancer on histology
- Microscopic colitis on histology
For the colitis group
- Simple clinical colitis activity index (SCCAI) score > 5
Type of Study:
Observational
Study Design:
Observational Model: Case Control, Time Perspective: Prospective
Outcome Measure:
Number of stem cells in the colonic crypt
Outcome Time Frame:
On day of endoscopy
Safety Issue:
No
Principal Investigator
Iain JD McCallum, MBChB MRCS
Investigator Role:
Principal Investigator
Investigator Affiliation:
Newcastle University, UK
Authority:
United Kingdom: National Health Service
Study ID:
McCallum-001
NCT ID:
NCT01075893
Start Date:
February 2010
Completion Date:
October 2012
Related Keywords:
- Colorectal Cancer
- Colorectal cancer
- Stem cells
- Ulcerative colitis
- Polyps
- Colorectal Neoplasms
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