`F-18 Fluorothymidine ([18F]FLT) PET Imaging for Early Evaluation of Response to Chemoradiation Therapy in Patients With Cervical Cancer
Subjects will undergo a total of 5 FLT PET scans.
Group 1 has FLT PET scans pretreatment, after 5 radiation treatments, after 10 radiation
treatments, after 15 radiation treatments, and then 1 month after completing radiation
Group 2 has FLT PET scans pretreatment, after 5 radiation treatments, after 10 radiation
treatments, after 20 radiation treatments, and then 1 month after completing radiation
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Standarized uptake values of the FLT tracer signal in both the tumor volume and bone marrow volume. Changes in uptake will be assessed compared to treatment outcome as well as blood cell counts.
baseline, weeks 1, 2, 3, and 4 of therapy, and 1 month post-therapy
Michael M Graham, Ph.D., M.D.
The University of Iowa
United States: Food and Drug Administration
|Holden Comprehensive Cancer Center||Iowa City, Iowa 52242-1009|