The Effect of Atorvastatin on Androgen Synthesis, Glucose Metabolism and Inflammation in Women With Polycystic Ovary Syndrome (PCOS). A Placebo Controlled Trial
30 women diagnosed for PCOS (aged 30-50 years) are enrolled for the study. 15 women are
randomized in the atorvastatin group and 15 in the placebo group. The women with PCOS
participating in the study are required to use safe non-hormonal contraception during the
The study includes transvaginal ultrasonography, serum samples, oral glucose tolerance test
(OGTT) and intra venous tolerance test (IVGTT) before and after receiving 6 months
atorvastatin 20mg/day therapy or placebo.
Measurements for androgen levels, pituitary hormones, glucose, insulin and inflammatory
markers are performed.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
0, 3, 6 months
Terhi T. Piltonen, MD, PhD
Dept Ob-Gyn, University of Oulu
Finland: Ethics Committee