Inclusion Criteria:

- Histological or cytological proof of transitional cell carcinoma (TCC) of the
bladder, urethra, ureter, or renal pelvis (urothelial carcinoma). Histology may be
mixed, but still requires a component of TCC.

- Measurable disease according to RECIST (version 1.1) and obtained by imaging within
30 days prior to registration for protocol therapy. Note: Sites of measurable disease
can not be within a previously irradiated site.

- Written informed consent and HIPAA authorization for release of personal health
information.

- Age > 18 years at the time of consent.

- Must have received only one prior chemotherapy regimen, which must have included one
of the following chemotherapeutic agents: cisplatin, carboplatin, or gemcitabine.
Note: Prior chemotherapy may have been administered in the perioperative
(neoadjuvant/adjuvant) or advanced/metastatic setting. Patients may have received
prior treatment with paclitaxel.

- Females of childbearing potential and males must be willing to use an effective
method of contraception (hormonal or barrier method of birth control; abstinence)
from the time consent is signed until 12 weeks after treatment discontinuation.

- Females of childbearing potential must have a negative pregnancy test within 7 days
prior to registration for protocol therapy.

- Females must not be breastfeeding.

Exclusion Criteria:

- No prior treatment with docetaxel.

- No symptomatic brain metastases. Patients with neurological symptoms must undergo a
head CT scan or brain MRI to exclude brain metastasis. NOTE: Patients with treated
brain metastasis must be off steroids and have completed radiation at least 14 days
prior to registration for protocol therapy.

- No prior malignancy is allowed except for adequately treated basal cell or squamous
cell skin cancer, in situ cervical cancer, Gleason < grade 7 prostate cancers, or
other cancers for which the patient has been disease-free for at least 5 years

- No treatment with any investigational agent or chemotherapeutic agent within 30 days
prior to registration for protocol therapy.

- No radiotherapy within 14 days prior to registration for protocol therapy. Patients
must have recovered from all radiotherapy-related toxicities.

- No major surgery within 30 days prior to registration for protocol therapy (major
surgery is defined by the use of general anesthesia).

- No minor surgery 14 days prior to registration for protocol therapy. NOTE: Insertion
of a vascular access device is allowed.

- No history of any medical condition resulting in ≥ CTC grade 2 dyspnea.

- Patients without long QT syndrome

- No history of labile hypertension or poor compliance with anti-hypertensive regimen
NOTE: No patients with systolic BP >140 mm Hg and/or diastolic BP > 90 mm Hg while on
medication for hypertension.

- No presence of atrial tachyarrhythmia (e.g., atrial fibrillation, atrial flutter,
multifocal atrial tachycardia, supraventricular tachycardia) if not effectively
rate-controlled.

- No history of a sustained ventricular tachycardia

- No history of ventricular fibrillation or Torsades de Pointes

- No right bundle branch block and left anterior or posterior hemiblock (bifascicular
block)

- No bradycardia defined as heart rate <50 beats per minute

- No concomitant use of drugs with risk of causing Torsades de Pointes.

- No concomitant use of drugs that are inducers and inhibitors of UGT1A9 and UGT2B7.