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The Efficacy of Coregistered Whole-Body Magnetic Resonance Imaging/Positron Emission Tomography (MRI/PET) in the Staging of Non-Small-Cell Lung Cancer

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Non-small Cell Lung Cancer

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Trial Information

The Efficacy of Coregistered Whole-Body Magnetic Resonance Imaging/Positron Emission Tomography (MRI/PET) in the Staging of Non-Small-Cell Lung Cancer

Non-small cell lung cancer (NSCLC) accounts for 75 to 80% of all lung cancers, and is
currently the leading cause of tumor-related deaths (1). Optimal lung cancer treatment
relies on accurate disease staging, which is based on tumor size and extent, regional nodal
involvement, and the presence of metastasis. Although thoracic CT has been considered the
standard modality of choice for assessing intrathoracic spread of lung cancer (2), no
consensus has been reached concerning metastasis evaluation. [18F]-fluorodeoxyglucose
(FDG)-positron emission tomography (PET) was introduced and developed as an integrated
modality for accurate nodal staging and for metastatic lesion detection in the whole body
(WB) (3-9). Currently, integrated PET/CT, by providing both morphologic and metabolic
features, appears to have achieved better efficacy in staging lung cancer than CT alone or
PET alone (8, 10).

Whole body magnetic resonance imaging (WB MRI) has become feasible and enables fast scan
throughout the body (11-13). This technique is based on a real-time gradient-echo imaging
and sliding table platform (rolling table concept, which eliminates time-consuming
repositioning of patients and surface coils). MRI scanners of the latest generation use high
field MRI units of > 1.5 Tesla (T), and are reported to have upgraded capabilities in terms
of temporal and spatial resolution due to improved signal-to-noise ratios (SNRs) under high
magnetic-field strength conditions (14, 15).

Because both integrated PET/CT and WB MRI can provide WB imaging, both modalities are used
for staging in patients with a malignant condition. According to a report (16), the
diagnostic efficacy of PET/CT is superior to WB MRI for T and N staging and similar to WB
MRI for detecting metastases. However, according to another study (17), WB MRI showed better
sensitivity than PET/CT for detecting metastatic lesions. In these studies (16, 17), in
which a 1.5T MR unit was used, the regional nodal or metastatic lesions were from various
types of primary malignancies with a wide range of tumor stages.

Recently we published a paper regarding the diagnostic efficacy comparison for determining
TNM stages of integrated PET/CT and 3T WB MRI in patients with an NSCLC (18). In this study,
we found that both PET/CT and 3T whole body MRI appear to provide acceptable accuracy and
comparable efficacy for non-small cell lung cancer staging, but in M stage determination,
each modality has its own advantages. Namely, WB MRI is more useful for detecting brain and
hepatic metastases, whereas PET/CT for lymph node and soft-tissue metastases. Therefore, we
suggested whole body MR/PET should be the future imaging modality for NSCLC staging
especially for M staging.

Although PET/CT scanners have quickly become established, development of MRI/PET has been
slower, due to the additional challenge of developing dual-modality systems that avoid
deleterious interactions caused by the high magnetic field environment of the MRI scanner
and radiofrequency (RF) interference between the PET and MRI systems. At this moment,
MRI/PET is still under development and is used only in small animal study (19). Thus, the
purpose of this research is to provide clinical corroborating data to show how effective
future MRI/PET will be in human use especially in patients with NSCLC by providing the
efficiency of side-by-side reading of WB MRI/PET as compared to PET/CT.

Inclusion Criteria:

- Patient with solitary pulmonary nodule under the suspicion of lung cancer

- Patients with NSCLC proved at pathologic examination will do PETCT as a routine
staging work-up.

Exclusion Criteria:

- patients with contraindication for the MR scan such as metalic device or

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Principal Investigator

Kyung Soo Lee, Prof.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Samsung Medical Center


South Korea: Institutional Review Board

Study ID:




Start Date:

February 2010

Completion Date:

October 2011

Related Keywords:

  • Non-Small Cell Lung Cancer
  • Magnetic Resonance Imaging/Positron Emission Tomography
  • Whole body imaging
  • Non-small cell lung cancer
  • staging
  • Diagnostic accuracy
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms