The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics
Aim of the work:
To study the effect of intrauterine injection of human chorionic gonadotrophin on the
endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial
It has been demonstrated that regulatory T cells expand during pregnancy and are present at
the feto-maternal interface at very early stages in pregnancy.
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg
cells and improve implantation.
Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check
for Treg cells and pinopodes.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic
the presence of Treg cells and pinopodes in the endometrium
Ragaa Mansour, MD,PhD
The Egyptian IVF-ET Center
Egypt: Ministry of Health, Drug Policy and Planning Center
hCG and Treg cells