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The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics


N/A
20 Years
38 Years
Not Enrolling
Female
Infertility

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Trial Information

The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics


Aim of the work:

To study the effect of intrauterine injection of human chorionic gonadotrophin on the
endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial
characteristics.

Background:

It has been demonstrated that regulatory T cells expand during pregnancy and are present at
the feto-maternal interface at very early stages in pregnancy.

Rational:

Intrauterine injection of hCG around the time of implantation may increase endometrial Treg
cells and improve implantation.

Methods:

Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check
for Treg cells and pinopodes.


Inclusion Criteria:



- Male factor infertility

- Ovulatory factor infertility

- Unexplained infertility

- Female age less than 39

Exclusion Criteria:

- Azoospermia

- Tubal factor infertility

- Pelvic endometriosis

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic

Outcome Measure:

the presence of Treg cells and pinopodes in the endometrium

Outcome Time Frame:

4 weeks

Safety Issue:

No

Principal Investigator

Ragaa Mansour, MD,PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

The Egyptian IVF-ET Center

Authority:

Egypt: Ministry of Health, Drug Policy and Planning Center

Study ID:

hCG and Treg cells

NCT ID:

NCT01064219

Start Date:

February 2010

Completion Date:

December 2010

Related Keywords:

  • Infertility
  • hCG
  • Treg cells
  • implantation
  • pinopodes
  • endometrium
  • Infertility
  • Adenoma

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