The Effect of Intrauterine Injection of Human Chorionic Gonadotrophins (hCG) on the Endometrial T-regulatory Cells and the Electronmicroscopic Endometrial Characteristics
Aim of the work:
To study the effect of intrauterine injection of human chorionic gonadotrophin on the
endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial
characteristics.
Background:
It has been demonstrated that regulatory T cells expand during pregnancy and are present at
the feto-maternal interface at very early stages in pregnancy.
Rational:
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg
cells and improve implantation.
Methods:
Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check
for Treg cells and pinopodes.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic
the presence of Treg cells and pinopodes in the endometrium
4 weeks
No
Ragaa Mansour, MD,PhD
Principal Investigator
The Egyptian IVF-ET Center
Egypt: Ministry of Health, Drug Policy and Planning Center
hCG and Treg cells
NCT01064219
February 2010
December 2010
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