Intraperitoneal Microdialysis Monitoring of Patients During the Early Postoperative Period After LAR With Reference to Early Diagnosis of Anastomotic Leakage Ore Other Complications
Patients undergoing LAR for rectum cancer is subjected to peritoneal microdialyses during
the postoperative period until the 7. postoperative day. Samples are collected every 4-hour.
Samples will be analyzed continuously but the results will not be included in the clinical
evaluation of the patient. Before removing the microdialysis catheter a CT whit rectal enema
is preformed. Every day the patient will be evaluated whit a standardised clinical scoring
system with attention at anastomotic leakage.
A total of 150 patients will be included in this study. The results of the peritoneal
microdialyses will be compared with the clinical scorings system in each patient. The
results form the uncomplicated courses will be used to define the normal variations in
peritoneal microdialysis. This will be compared to results from patients with various
The study is approved by the local scientific ethical committee No. ------
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Significant elevated peritoneal microdialysis parameter like lactate and L/P-ratio
Clinically complications with in 30th days after surgery
Denmark: The Regional Committee on Biomedical Research Ethics