Inclusion Criteria:

- Females ≥18 years of age

- Undergoing annual breast MRI because of a high risk of breast cancer due to any of
the following:

- Known BRCA1 or BRCA2 mutation carriers, or is untested for BRCA but is a first
degree relative of a BRCA mutation carrier

- History of radiation to the chest between 10-30 years of age (e.g. Hodgkin's
Disease)

- History of Cowdens or Li Fraumeni Syndrome

- A first degree relative with Cowdens or Li Fraumeni Syndrome

- Prior breast biopsy positive for lobular carcinoma in situ (LCIS) or atypical
lobular hyperplasia or atypical ductal hyperplasia (ADH)

- Family history consistent with a hereditary breast cancer syndrome and estimated
personal lifetime cancer risk ≥25% using the IBIS risk evaluator

Exclusion Criteria:

- Pregnant or lactating

- History of invasive breast cancer or ductal carcinoma in situ (DCIS)

- Unable to undergo MRI because of:

- Renal dysfunction with an estimated creatinine clearance of < 30 ml/min
calculated using the Cockcroft-Gault formula

- Implanted ferrous metal prostheses

- Claustrophobia

- Medical or psychological conditions that on assessment, make them unable to
complete the procedure

- Known allergies to Gadolinium-DTPA

- Known allergies to Sestamibi (Miraluma or Cardiolite)

- Prior bilateral mastectomy

- Prior breast biopsy or surgery within 3 months