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Peripheral Blood Telomere Length as a Biomarker of Advanced Colorectal Adenomas

50 Years
60 Years
Open (Enrolling by invite only)
Colonic Polyp

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Trial Information

Peripheral Blood Telomere Length as a Biomarker of Advanced Colorectal Adenomas

Telomeres are the repetitive DNA sequences that cap both ends of chromosomes. Shortening of
peripheral blood lymphocyte (PBL) telomeres has been associated with renal and other
cancers. The investigators' preliminary data shows an association between shorter PBL
telomere length and ACPs.

I. Specific Aims

1. Develop a DNA and data repository from individuals with advanced colon polyps (ACPs)
and controls

2. Confirm that individuals 50 to 60 years of age with ACPs tend to have shorter
peripheral blood lymphocyte (PBL) telomeres than those without ACPs

3. Identify a potential optimal PBL telomere length cut-off to differentiate between
individuals with ACPs and those without for evaluation in a larger scale study

The over reaching long term goal is to decrease disease and death from colorectal cancer
(CRC) using a biomarker strategy to target colonoscopy to those at higher risk.

Inclusion Criteria:

Advanced Colon Polyp Group (ACP):

- Must be 50 to 60 years of age with an advanced colon polyp (ACP: advanced colon
polyps are those larger than 10 mm, or a colon polyp with high grade dysplasia, or a
colon polyp with villous features.

Control Group (Controls):

- Must be 50 to 60 years of age and have had a negative screening colonoscopy.

- Controls will also have no history of adenomatous colorectal neoplasia.

Exclusion Criteria:

- Subjects under 50 years of age

- Subjects over 60 years of age

- Subjects with colon polyps less than 10 mm in size

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

Telomere length are shorter in individuals with colon polyps.

Outcome Time Frame:

2 years

Safety Issue:


Principal Investigator

Douglas L Riegert-Johnson, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic


United States: Institutional Review Board

Study ID:




Start Date:

January 2010

Completion Date:

October 2013

Related Keywords:

  • Colonic Polyp
  • Advanced colon polyp
  • Adenomatous colon polyp
  • Adenoma, villous colon polyp
  • Advanced colorectal adenomas
  • Colonic neoplasms
  • High grade dysplasia
  • Telomere blood testing
  • Colonic Polyps
  • Polyps



Mayo Clinic Jacksonville Jacksonville, Florida  32224