Peripheral Blood Telomere Length as a Biomarker of Advanced Colorectal Adenomas
Telomeres are the repetitive DNA sequences that cap both ends of chromosomes. Shortening of
peripheral blood lymphocyte (PBL) telomeres has been associated with renal and other
cancers. The investigators' preliminary data shows an association between shorter PBL
telomere length and ACPs.
I. Specific Aims
1. Develop a DNA and data repository from individuals with advanced colon polyps (ACPs)
2. Confirm that individuals 50 to 60 years of age with ACPs tend to have shorter
peripheral blood lymphocyte (PBL) telomeres than those without ACPs
3. Identify a potential optimal PBL telomere length cut-off to differentiate between
individuals with ACPs and those without for evaluation in a larger scale study
The over reaching long term goal is to decrease disease and death from colorectal cancer
(CRC) using a biomarker strategy to target colonoscopy to those at higher risk.
Observational Model: Case Control, Time Perspective: Prospective
Telomere length are shorter in individuals with colon polyps.
Douglas L Riegert-Johnson, M.D.
United States: Institutional Review Board
|Mayo Clinic Jacksonville||Jacksonville, Florida 32224|