Inclusion Criteria:

- For the first part of the study: histologically or cytologically confirmed solid
cancer with evidence of advanced disease for which no other standard treatment is
available or appropriate. For the second part of the study: Histologically or
cytologically confirmed advanced RCC.

- Patients must have at least one measurable lesion as detected by computed tomography
(CT).

- All acute toxic effects (excluding alopecia) of any prior therapy must have resolved
to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events
(CTCAE) (v3.0) Grade
- Patients who have received autologous marrow/stem cell infusion using monoclonal
antibody-purged specimens are eligible.

- Adult patients of both sexes aged 18 years or older.

- Eastern Cooperative Oncology Group (ECOG) performance status
- Sufficient haematological, liver and renal function:

- Absolute neutrophil count (ANC) >/=1.5 x 109/L, platelets >/=100 x 109/L, haemoglobin
(Hb) >/=9.0 g/dL,

- Alkaline phosphatase (AP) aminotransferase (ALT) and/or aspartate aminotransferase (AST) bilirubin <1.5 x ULN; however, in the presence of liver metastases, AP ALT and/or AST
- Creatinine /=50 mL/min.

- Pulse oximetry >94% on room air.

- Negative serum pregnancy test for females of childbearing potential within 14 days of
starting treatment.

- Life expectancy of at least 3 months.

- Evidence of a personally signed and dated informed consent indicating that the
patient (or legally acceptable representative) has been informed of all pertinent
aspects of the study.

- Willingness and ability to comply with the scheduled visits, treatment plan,
laboratory tests and other study procedures.

- Negative human immunodeficiency virus (HIV) test 2 to 3 weeks before administration
of study treatment (with informed consent for test taken).

Exclusion Criteria:

- Presence of active infections (eg requiring antibiotic therapy) or other severe
concurrent disease, which, in the opinion of the investigator, would place the
patient at undue risk or interfere with the study.

- Presence of known brain metastases.

- Chronic aggressive hepatitis or active autoimmune diseases.

- History within the last year of acute or subacute coronary syndromes including
myocardial infarction, unstable or severe stable angina pectoris.

- Heart insufficiency (>Grade II New York Heart Association [NYHA] criteria).

- Irreversible cardiac arrhythmias requiring permanent medication.

- Uncontrolled hypertension.

- Ischaemic peripheral vascular disease (Grade IIb-IV).

- Severe rheumatoid arthritis.

- Severe diabetic retinopathy.

- Recovery from major trauma including surgery within 4 weeks of administration of
study treatment.

- Known history of allergy to intravenously administered proteins/peptides/antibodies.

- Pregnancy or breast feeding. Female patients must agree to use effective
contraception, or be surgically sterile or postmenopausal. The definition of
effective contraception will be based on the judgement of the principal investigator
or a designated associate.

- Chemotherapy (standard or experimental) within 4 weeks of the administration of study
treatment, or 6 weeks for nitrous ureas, l-phenylalanine mustard (LPAM) or
temozolamide.

- Radiation therapy within 4 weeks of the administration of study treatment.

- Previous in vivo exposure to monoclonal antibodies for biological therapy in the 6
weeks before administration of study treatment.

- Growth factors or immunomodulatory agents within 7 days of the administration of
study treatment.

- Prior allografts (including bone marrow or stem cells).

- Patient requires or is taking corticosteroids or other immunosuppressant drugs on a
long term basis. Limited use of corticosteroids to treat or prevent acute
hypersensitivity reactions is not considered an exclusion criterion.

- Investigational study drug taken within 4 weeks of the administration of study
treatment or concurrent treatment with other anti-cancer therapy.