Critical Role of MicroRNA-34a and MicroRNA-194 in Acute Myeloid Leukemia With CEBPA Mutations
N/A
N/A
Both
Leukemia
Trial Information
Critical Role of MicroRNA-34a and MicroRNA-194 in Acute Myeloid Leukemia With CEBPA Mutations
OBJECTIVES:
- To determine the significance of regulation of microRNA-34a and microRNA-194 by C/EBPα
during granulopoiesis in patients with acute myeloid leukemia with CEBPA mutations.
- To determine whether overexpression of micro RNA-34a and microRNA-194 in myeloid
progenitors with C/EBPα mutations leads to granulocytic differentiation.
- To examine how microRNA-34a and microRNA-194 downregulate E2F3 during granulopoiesis.
- To determine the role of microRNA-34a and microRNA-194 in myeloid cell proliferation.
OUTLINE: Cryopreserved cell samples are collected for laboratory analysis, including
mutation analysis, gene expression analysis, RNA analysis, and fluorescence-activated cell
sorting (FACS) analysis.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of acute myeloid leukemia with CEBPA mutations
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Significance of regulation of microRNA-34a and microRNA-194 by C/EBPα during granulopoiesis
Safety Issue:
No
Principal Investigator
Soheil Meshinchi, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fred Hutchinson Cancer Research Center
Authority:
United States: Federal Government
Study ID:
CDR0000664229
NCT ID:
NCT01057199
Start Date:
January 2010
Completion Date:
Related Keywords:
- Leukemia
- adult acute myeloid leukemia
- childhood acute myeloid leukemia/other myeloid malignancies
- Leukemia
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid
Name | Location |
|---|
