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Mechanisms of PLAGL2-Induced Leukaemogenesis


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Leukemia

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Trial Information

Mechanisms of PLAGL2-Induced Leukaemogenesis


OBJECTIVES:

- Screen acute myeloid leukemia (AML) samples to correlate high relative expression
levels of PLAGL2 and putative PLAGL2 target genes (implicated in microarray study) with
potential pathogenic relevance with respect to AML development.

OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by
reverse transcriptase-PCR.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of acute myeloid leukemia, including inv(16)(p13;q22) abnormalities

- No t(15;17)(q22;q12) or t(8;21)(q22;q22) abnormalities

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Correlation of high relative expression levels of PLAGL2 and putative PLAGL2 target genes with potential pathogenic relevance

Safety Issue:

No

Principal Investigator

Soheil Meshinchi, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

CDR0000664240

NCT ID:

NCT01057095

Start Date:

January 2010

Completion Date:

Related Keywords:

  • Leukemia
  • adult acute myeloid leukemia with inv(16)(p13;q22)
  • adult acute myeloid leukemia with 11q23 (MLL) abnormalities
  • adult acute myeloid leukemia with del(5q)
  • adult acute myeloid leukemia with t(16;16)(p13;q22)
  • adult acute myeloid leukemia in remission
  • recurrent adult acute myeloid leukemia
  • untreated adult acute myeloid leukemia
  • childhood acute myeloid leukemia in remission
  • recurrent childhood acute myeloid leukemia
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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