Trial Information
Mechanisms of PLAGL2-Induced Leukaemogenesis
OBJECTIVES:
- Screen acute myeloid leukemia (AML) samples to correlate high relative expression
levels of PLAGL2 and putative PLAGL2 target genes (implicated in microarray study) with
potential pathogenic relevance with respect to AML development.
OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by
reverse transcriptase-PCR.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of acute myeloid leukemia, including inv(16)(p13;q22) abnormalities
- No t(15;17)(q22;q12) or t(8;21)(q22;q22) abnormalities
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Correlation of high relative expression levels of PLAGL2 and putative PLAGL2 target genes with potential pathogenic relevance
Safety Issue:
No
Principal Investigator
Soheil Meshinchi, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fred Hutchinson Cancer Research Center
Authority:
United States: Federal Government
Study ID:
CDR0000664240
NCT ID:
NCT01057095
Start Date:
January 2010
Completion Date:
Related Keywords:
- Leukemia
- adult acute myeloid leukemia with inv(16)(p13;q22)
- adult acute myeloid leukemia with 11q23 (MLL) abnormalities
- adult acute myeloid leukemia with del(5q)
- adult acute myeloid leukemia with t(16;16)(p13;q22)
- adult acute myeloid leukemia in remission
- recurrent adult acute myeloid leukemia
- untreated adult acute myeloid leukemia
- childhood acute myeloid leukemia in remission
- recurrent childhood acute myeloid leukemia
- untreated childhood acute myeloid leukemia and other myeloid malignancies
- Leukemia
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid