Inclusion Criteria:

- Healthy male subjects aged 18 to 45 years (included), and in good health as
determined by past medical history, physical examination, vital signs,
electrocardiogram, and laboratory tests at screening

- Subjects must be able to communicate well with the investigator, to understand and
comply with the requirements of the study, and to understand and sign the written
informed consent

Exclusion Criteria:

- Evidence of current or previous clinically significant disease, medical condition or
finding of the medical examination (including vital signs and ECG), that in the
opinion of the investigator would compromise the safety of the subject or the quality
of the data

- Current or recent history of significant renal, hepatic, haematological,
immunological, gastrointestinal, endocrine, pulmonary, cardiac, neurological, or
cerebral disease which would interfere with the subject's participation in the trial