Inclusion Criteria:

- Histologically proven unresectable, non-metastatic pancreatic adenocarcinoma with
measurable or evaluable disease and without involvement of the duodenum

- Performance Status 0-2

- No prior anticancer therapy for pancreatic adenocarcinoma

- No prior anticancer therapy of any kind within the last 5 years

- Adequate hepatic, bone marrow, and renal function

- Life expectance of > 12 weeks

- Women of childbearing potential must have a negative serum pregnancy test

Exclusion Criteria:

- Duodenal involvement of pancreatic cancer

- Metastatic cancer

- Active severe infection, or known chronic infection with HIV, hepatitis B virus, or
hepatitis C virus

- Cardiovascular disease including unstable angina, therapy for life-threatening
ventricular arrhythmia, myocardial infarction, stroke, or congestive heart failure
within the last 6 months

- Life-threatening visceral disease or other severe concurrent disease

- Pregnant or breastfeeding

- Anticipated patient survival under 3 months

- Another active malignancy within the past 5 years except for cervical cancer in situ,
in situ carcinoma of the bladder or non-melanoma carcinoma of the skin.