Inclusion Criteria:

- 18 years of age or older and ability to adequately understand and give informed
consent

- Local (prostate or prostate bed) recurrent CRPC or metastatic disease to soft tissue
or bone at sites accessible to biopsy with minimal risk of complications

- Platelet count >50,000; WBC >2,000, Hgb >8.0, INR<1.5; PTT<45

- No history of excessive unexplained bleeding from previous surgery

- One of the following:

- Metastatic castration sensitive prostate cancer or;

- Castration resistant prostate cancer as defined by serum testosterone < 50 ng/ml
and one of the following:

- PSA level of at least 2 ng/ml that has risen on at least 2 successive occasions
at least 1 week apart. Evaluable disease progression by modified RECIST
(Response Evaluation Criteria in Solid Tumors)

- Progression of metastatic bone disease on bone scan with > 2 new lesions

Exclusion Criteria:

- Patients unable to stop chronic anticoagulation with warfarin or lovenox for less
than 3 days

- Serious or uncontrolled infection

- Treatment with a VEGF inhibitor (such as Avastin) within the past 28 days.