Inclusion Criteria:

- Age >18

- Histological or cytological diagnosis of adeno- or undifferentiated non-small cell
carcinoma of pancreas.

- Considered to be unresectable based on following: extensive peri-pancreatic lymph
node involvement, encasement or occlusion of the SMV or SMV/portal vein confluence,
direct involvement of SMA, coeliac axis, inferior vena cava or aorta.

- Performance status 0-2

- No evidence of metastatic disease as determined by CT scan/ other investigations

- Adequate bone marrow function with platelets>100^9/l; WBC>3x10^9/l;neutrophils>
1.5x10^9/l

- Serum bilirubin ,1.5 x ULN and transaminases < 2.5 x ULN

- Calculated/measured GFR >50ml/min

- No concurrent uncontrolled medical condition

- No active malignant disease other than non-melanotic skin cancer or carcinoma in situ
of the uterine cervix over the last 10 years

- Life expectancy > 3months

- Adequate contraceptive precautions

- Informed written consent

Exclusion Criteria:

- medical or psychiatric conditions that compromise the patient's ability to give
informed consent

- Presence of met. disease

- Concurrent uncontrolled medical conditions

- Any previous chemo/RT or any investigational treatment for advanced pancreatic
cancer.

- Adjuvant chemo + fluoropyrimidine or gemcitabine within 12months of trial entry

- Adjuvant RT with/without chemo for pancreatic cancer.

- Pregnancy/breast feeding

- Patients with known malabsorption syndromes ro a lack of physical treatment of the
upper GI tract.

- Patients with a known hypersensitivity to 5-FU or with a DPD deficiency.

- Clinically significant CVD