Inclusion Criteria:

- Patient has a diagnosis of Stage IV pancreatic adenocarcinoma with distant metastases

- Patient is scheduled to receive standard chemotherapy containing gemcitabine

- Patient has not received prior systemic therapy for advanced pancreatic
adenocarcinoma

- Patient must be available for periodic blood sampling, study-related assessments, and
management at the treating institution

Exclusion Criteria:

- Patient has had open abdominal surgery within 6 weeks of the screening visit

- Patient has had radiotherapy to the thorax, abdomen, or pelvis within 6 months of the
screening visit

- Patient has an active infection, inflammation, or unresolved bowel obstruction

- Patient has poorly controlled diabetes