Inclusion Criteria:

- Patients with proven CHD by coronary angiography demonstrating occlusion or extreme
stenosis (> 90%) of a coronary artery (target artery) not suitable for angioplasty or
surgery.

- Angiographic criteria: Feasibility for balloon catheter placement without risks of
obstruction of the left main coronary trunk.

- Evidence of viable myocardial tissue in the area irrigated by the target artery by
MRI (low dose dobutamine and late enhancement).

- CCS class 2-4 angina pectoris (angina pectoris at rest and at light exertion, obvious
reduction in the exertion capacity).

- Optimal antianginal pharmacologic therapy (consistent with the current guidelines of
ACC (American College of Cardiology), as well as the DGK (Deutsche Gesellschaft für
Kardiologie)

- Signed written consent form accepted by the Ethics Committee.

- Effective contraception in women of child-bearing age.

Exclusion Criteria:

- Severe symptomatic heart failure (NYHA class 4).

- Myocardial aneurysm (in the target region) without evidence of viable myocardium.

- Myocardial infarction in the last 4 weeks.

- Symptomatic ventricular tachycardia.

- Known malignancy.

- Known hematological disease.

- Renal insufficiency with creatinine > 2.5 mg/dl.

- Pregnancy.

- Active chronic inflammatory bowel disease or rheumatic disease with high parameters
of inflammation (WBCs above 10/nl and increased C-reactive protein). Systemic steroid
administration.

- Severe coagulopathy or phenprocoumon type anticoagulation therapy at the time of bone
marrow extraction.

- Antiproliferative therapy (chemotherapy, etc.).

- Non accordance with procedures and follow-up studies.

- Contraindications to MRI studies.

- Known hypersensitivity against mouse immunoglobulins.

- Known hypersensitivity against ferridextran.

- Contraindications for bone marrow extraction.

- Cerebrovascular accident in the past four months.