Lacritin and Heparanase Levels in Human Tears After Laser Refractive Surgery
Lacritin is a naturally occurring tear protein with antimicrobial activity that is capable
of stimulating mitogenesis in human corneal epithelial cells and promoting production of
tears in lacrimal gland acinar cells. A recently developed immunoassay for lacritin may help
characterize the lacritin response following refractive surgery with the possible
development of recombinant lacritin as a novel therapeutic agent for wound healing.
Heparanase (HPSE) acts as a regulator for lacritin by cleaving heparan sulfate chains and
allowing lacritin to bind. We aim to measure both tear lacritin and HPSE pre- and
post-operatively to elucidate lacritin and HPSE's response in patients undergoing PRK
(photorefractive keratectomy) and LASIK (Laser-assisted in situ keratomileusis) at the
Walter Reed Center for Refractive Surgery.
Observational Model: Cohort, Time Perspective: Prospective
The primary outcome measure is tear lacritin levels pre- and post-surgery.
pre and standard visits up to 6 months post-surgery
Kraig S. Bower, MD
Walter Reed Army Medical Center
United States: Federal Government
|Walter Reed National Military Medical Center||Bethesda, Maryland 20889|
|Fort Belvoir Community Hospital||Fort Belvoir, Virginia 22060|