Phase II Study of Proton Radiation Therapy for CNS Germ Cell Tumors: Evaluation of Acute and Late Side Effects
- Before participants begin radiation therapy they will have scans done to prepare them
for radiation treatment. Doctors will use the information gathered from these scans to
plan the best way to deliver radiation to the tumor.
- Participants will receive treatment as an outpatient at the Francis H. Burr Proton
Center located at the Massachusetts General Hospital.
- Not everyone who participates in this study will receive the same amount of proton
radiation therapy. The length of time and amount of radiation that the participant
will receive will depend on the type of germ cell tumor they have and the stage of the
- Radiation treatment will be given once a day, 5 days a week (Monday-Friday), for 4-8
weeks depending on the condition of the participant's disease.
- During each week of proton radiation therapy, participants will have a physical exam
and be asked questions about their general health and any problems they might be
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To describe late complications of craniospinal, whole ventricle, and involved field radiation therapy delivered with proton radiotherapy in place of photon radiation for this patient population.
Shannon MacDonald, MD
Massachusetts General Hospital
United States: Institutional Review Board
|Dana-Farber Cancer Institute||Boston, Massachusetts 02115|
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|