The Adjuvant Effect of Berry Extract on Triple Therapy for Helicobacter Pylori Eradication
18 Years
N/A
Both
Increase the Eradication Rate of Helicobacter Pylori
Trial Information
The Adjuvant Effect of Berry Extract on Triple Therapy for Helicobacter Pylori Eradication
One-week of triple therapy composed of a proton pump inhibitor plus two antibiotics is
currently regarded as the gold standard for HP eradication. However, the eradication rate
continues to be disappointing. Poor patient compliance and bacterial resistance are the main
factors contributing to treatment failure. Therefore, it is urgently necessary to develop a
non-antibiotic alternative therapy to increase the eradication rates of Helicobacter pylori.
Some literatures reported that cranberry may inhibit Helicobacter pylori adhesion to the
human gastric mucus and may reduce Helicobacter pylori infection in adults. The aims of his
experiment were to explore the impact of berry extract on triple therapy for Helicobacter
pylori eradication.
Inclusion Criteria:
- Patients older than 18
Exclusion Criteria:
- Pregnancy or breastfeeding
- Use of antibiotics 2 weeks prior to inclusion
- Previous eradication treatment
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Outcome Measure:
Eradication rate
Outcome Time Frame:
4 weeks after Eradication of Helicobacter pylori
Safety Issue:
Yes
Principal Investigator
Shih-Yi Huang, Ph.D
Investigator Role:
Principal Investigator
Investigator Affiliation:
Taipei Medical University
Authority:
Taiwan: Department of Health
Study ID:
SKH-TMU-98-02
NCT ID:
NCT01045408
Start Date:
January 2009
Completion Date:
June 2010
Related Keywords:
- Increase the Eradication Rate of Helicobacter Pylori
- Helicobacter pylori
- Berry extract
- Triple therapy
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