Virtual HDR CyberKnife Radiosurgery for Localized Prostatic Carcinoma: A Phase II Study
Brachytherapy is a form of treatment where a radioactive isotope is implanted directly into
a tumor volume to deliver a lethal dose of radiation. High Dose Rate (HDR) Prostate
brachytherapy is a particularly elegant brachytherapy dose sculpting method that is
effectively used in the curative treatment of prostate cancer; however, it requires hospital
admission and many temporarily implanted transperineal catheters to deliver the radiation
source to the target volume, resulting in significant patient discomfort. CyberKnife
delivers a form of radiation treatment that is so precise, it appears capable of
reconstructing HDR prostate radiation dose sculpting, without the hospital admission and
without the catheters. The CyberKnife device is also used for classic radiosurgery, with
accuracy comparable to the Gamma Knife, but unlike the Gamma Knife, has the capability to
target lesions anywhere in the body with similar accuracy. The aim of this study is to
compare CyberKnife morbidity and efficacy with that of HDR and other local treatment methods
such a permanent seed prostate brachytherapy in the treatment of prostate cancer.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To evaluate the effects of CK prostate radiosurgery in terms of morbidity/QOL, relative to other commonly used methods of prostate cancer treatment and the pattern of PSA decline and biochemical relapse-free survival thereafter.
Donald B Fuller, M.D.
CyberKnife Centers of San Diego/Radiation Medical Group- Genesis Healthcare Partners
United States: Institutional Review Board
Virtual HDR CK Radiosurgery
|CyberKnife Centers of San Diego||San Diego, California 92101|