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Comedy in Chemotherapy (COMIC) Study

Phase 2
21 Years
Not Enrolling
Cancer, Chemotherapy

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Trial Information

Comedy in Chemotherapy (COMIC) Study

Patients were recruited from the Outpatient Oncology (OPO) clinic at QMC. After signing an
informed consent, patients receiving intravenous chemotherapy were randomly assigned to view
a 45-minute humorous DVD or non-humorous DVD. The following measurements were obtained
before and after patients viewed the DVD: Edmonton Symptom Assessment Scale (ESAS) and the
state portion of the Spielberger State-Trait Anxiety Index (STAI-S) to assess symptoms
related to cancer and chemotherapy, salivary immunoglobulin A (IgA) to assess immune
function and salivary cortisol to assess emotional stress. In addition, patients,
caregivers, and nurses were asked open-ended questions after the intervention to ascertain
their impression of the overall intervention experience. Multiple analysis of covariance
(MANCOVA) were be used to analyze changes in ESAS, STAI-S, IgA and cortisol within and
between the two groups.

Inclusion Criteria:

1. Diagnosis of cancer

2. Receiving intravenous chemotherapy in the OPO clinic at QMC

3. Has a minimum appointment time in OPO of two hours

4. Age 21 or older

5. Speaks English

Exclusion Criteria:

1. Blind

2. Deaf

3. Diagnosis of head/neck cancer

4. Severe oral mucositis

5. Cognitively impaired


Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Outcome Measure:

To compare changes in symptoms related to cancer and chemotherapy after a humor vs. non-humor intervention

Outcome Time Frame:

One day

Safety Issue:


Principal Investigator

Hob Osterlund, RN, MS

Investigator Role:

Principal Investigator

Investigator Affiliation:

The Queen's Medical Center


United States: Institutional Review Board

Study ID:




Start Date:

February 2007

Completion Date:

January 2009

Related Keywords:

  • Cancer
  • Chemotherapy
  • Cancer
  • Humor
  • Distraction
  • Comedy
  • Chemotherapy



The Queen's Medical CenterHonolulu, Hawaii  96813