Genomic and Proteomic Profiling of Childhood AML
- To profile basal and potentiated phospho-protein networks (PPPNs) using tissue samples
from pediatric patients with de novo acute myeloid leukemia (AML) previously enrolled
on clinical trial POG-9421.
- To classify AML-based signal transduction mechanisms.
- To correlate profiles of basal and PPPNs with specific molecular lesions (e.g.,
FLT3-ITD, NPM, WT1, c-kit, CEPBα, PASGΔ75, and karyotype) and profiles of gene
expression in tumor tissue samples.
OUTLINE: Banked tissue samples are collected for laboratory studies, including
phospho-protein signaling and gene expression profiling studies.
Profiling of basal and potentiated phospho-protein networks (PPPNs) using tissue samples
Norman J. Lacayo, MD
United States: Federal Government