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Multicenter Prospective Randomized Trial Comparing Standard Esophagectomy With Chemoradiotherapy for Treatment of Squamous Esophageal Cancer: Early Results From the Chinese University Research Group for Esophageal Cancer (CURE)


Phase 3
18 Years
75 Years
Not Enrolling
Both
Esophageal Cancers

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Trial Information

Multicenter Prospective Randomized Trial Comparing Standard Esophagectomy With Chemoradiotherapy for Treatment of Squamous Esophageal Cancer: Early Results From the Chinese University Research Group for Esophageal Cancer (CURE)


Inclusion Criteria:



- Eligible patients had mid or lower thoracic esophageal cancers that were confirmed on
histology to be a squamous cell carcinoma deemed to be resectable.

Exclusion Criteria:

- The investigators excluded those patients who had distant metastasis to solid
visceral organs or local invasion into trachea, descending aorta, or recurrent
laryngeal nerve.

- Those patients who were older than 75 years or who had a serious premorbid condition
or a poor physical status that compromised a thoracotomy were also excluded.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Overall survival and disease-free survival

Outcome Time Frame:

2 year and 5 year

Safety Issue:

Yes

Principal Investigator

Philip W Chiu, FRCSEd (Gen)

Investigator Role:

Principal Investigator

Investigator Affiliation:

Chinese University of Hong Kong

Authority:

Joint CUHK-NTEC Clinical Research Ethics Committee, Hong Kong:

Study ID:

Surgery or CRT Ca Esophagus

NCT ID:

NCT01032967

Start Date:

July 2000

Completion Date:

June 2009

Related Keywords:

  • Esophageal Cancers
  • squamous cell carcinoma
  • esophagectomy
  • chemoradiotherapy
  • chemoradiation
  • Squamous cell carcinomas of the esophagus
  • Esophageal Diseases
  • Esophageal Neoplasms

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