The Neuroendocrine, Metabolic, Inflammatory and Immune Responses to Routine Head and Neck Surgery. An Observational Pilot Study
This project is in keeping with the strategy of the anaesthetic and intensive care
departments to push towards greater understanding of the immune, metabolic and inflammatory
changes associated with surgery and how these may be modified through use of different
anaesthetic and intensive care techniques. Through increased understanding of the stress,
inflammatory and immune responses to surgery we may be able to modulate peri-operative care
to reduce cytotoxic(Natural Killer and Cytotoxic T cell) immunosuppression and hence
micrometastatic spread at the time of surgery in future studies.
Observational Model: Cohort, Time Perspective: Prospective
The maximum increase (from baseline to day 3 post-op) in cortisol, IL1 and IL6 will be calculated together with their standard deviations.
Dr Craig Carr
The Royal Marsden NHS Foundation Trust
United Kingdom: Research Ethics Committee