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Effect of Surgery and Radiation Therapy on Tc-99M Sestamibi Uptake Patterns in Molecular Breast Imaging


N/A
18 Years
90 Years
Not Enrolling
Female
Breast Cancer

Thank you

Trial Information

Effect of Surgery and Radiation Therapy on Tc-99M Sestamibi Uptake Patterns in Molecular Breast Imaging


The study will allow us to evaluate whether surgery and radiation have persistent effects on
the breast tissue with regards to whether and how such changes impact MBI images and to
determine whether the inflammatory changes due to treatment resolve within 6-12 months of
completing treatment.


Inclusion Criteria:



- Women who have planned surgical excision of a lesion or have had a baseline MBI study
as part of another MBI research protocol who are within 6-12 months of completing
breast surgery who are able and willing to return to Mayo Clinic for a follow up MBI
study once the 6-12 month interval is complete.

- Women who plan BCT for a malignant lesion or who are within 6-12 months of completing
breast conserving treatment and have had a baseline MBI study as part of another MBI
research protocol and are able and willing to return to Mayo Clinic for a follow up
MBI study.

Exclusion Criteria:

- Women who do not require surgical excision of a breast lesion or breast conserving
treatment for breast cancer.

- Patients undergoing mastectomy.

- Women who are pregnant or lactating.

- Women who are taking hormonal contraception or hormone replacement therapy (vaginal
estrogen is permitted), or have used these agents within the previous 3 months.

- Women who have received chemotherapy within the previous 6 months or receive
chemotherapy as part of their cancer treatment.

- Men (due to the very low incidence of male breast cancer and the lack of any
available data regarding the use of scintimammography or MBI in men).

- Women under the age of 18 years.

- Women unable to sit comfortably during image acquisition.

- Women who are unable to return to Mayo Clinic for a follow up MBI scan 6-12 months
after surgical excision or 6-12 months after completing radiation therapy for breast
conservation.

Type of Study:

Observational

Study Design:

Observational Model: Cohort

Principal Investigator

Nicole Sandhu, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic

Authority:

United States: Institutional Review Board

Study ID:

09-000455

NCT ID:

NCT01027767

Start Date:

May 2009

Completion Date:

September 2012

Related Keywords:

  • Breast Cancer
  • Breast
  • MBI
  • Molecular
  • Molecular Breast Imaging
  • Dense breast tissue
  • Surgery
  • Radiation
  • BCT
  • Breast Neoplasms

Name

Location

Mayo ClinicRochester, Minnesota  55905