Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells
N/A
N/A
Both
Cancer
Trial Information
Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells
- Validate the clinical use of a mircofluidic device to capture circulating timor cells
from a broad range of tumor types
- Characterize and identify these circulating tumor cells and demostrate cell viability
with this capture method
- Apply this technology in clinically relevant settings and correlate to response to
treatment and disease progression
- Elucidate predictive and pharmacodynamic biomarkers in the context of early phase
trials of novel therapeutics
Inclusion Criteria:
- Patients with newly diagnosed metastatic disease planned for palliative chemotherapy
- Tumor types as specified: non smokers with lung adenocarcinoma, undifferentiated
EBV-ISH positive nasopharyneal carcinoma, breast cancer, colorectal cancer, prostate
cancer, gastric cancer
- Informed consent given for the purposes of blood sampling for this study
- Measurable disease by RECIST criteria of at least 1cm is preferred but not a sine qua
non for study accrual
Exclusion Criteria:
- N/A
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Principal Investigator
Wan-Teck Lim, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
National Cancer Centre, Singapore
Authority:
Singapore: Health Sciences Authority
Study ID:
CTC_ver2_081109
NCT ID:
NCT01022723
Start Date:
October 2009
Completion Date:
December 2013
Related Keywords:
- Cancer
- Circulating tumor cells
- metastasis
- cancer
- cell isolation
- mircofludics
- cell detection
- Neoplastic Cells, Circulating
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