Multimodality Statistical Model of Early Response of High Grade Glioma to Radiation Therapy
I. To develop a multimodality statistical model to act as a surrogate marker scheme of early
changes in high grade glioma patients undergoing radiation therapy, using conventional MRI,
MR diffusion tensor imaging, perfusion, permeability, and spectroscopic imaging while
incorporating the radiation dose calculations delivered locally and the results of a
clinical questionnaire into the model.
II. To assess treatment response to tumor and normal tissue changes. OUTLINE: Patients
undergo multimodality MRI imaging at baseline, weeks 1, 2, 3, 5, and 6, and then 4-6 weeks
after completion of radiation therapy.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Early brain tumor response
United States: Institutional Review Board
|Abramson Cancer Center of the University of Pennsylvania||Philadelphia, Pennsylvania 19104-4283|