Inclusion Criteria:

- Histological diagnosis of NSCLC with locally advanced or metastatic disease that is
of non-squamous histology.

- Patients must be "light ex-smokers" or "never-smokers".

- "Light ex-smokers" defined as having ceased smoking for greater than or equal to
5 years and not to have exceeded 10 pack-years.

- "Never-smokers" are defined as having smoked <100 cigarettes or equivalent
during his/her lifetime.

- Patients must be of East Asian ethnicity.

- No prior systemic therapy for lung cancer.

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Exclusion Criteria:

- Presence of clinically significant (by physical exam) third-space fluid collections,
for example, ascites or pleural effusions that cannot be controlled by drainage or
other procedures prior to study entry.

- Any evidence of clinically active interstitial lung disease. Asymptomatic patients
with chronic, stable, radiographic changes are eligible.

- Patients whose Epiderla growth Factor Receptor (EGFR) mutation status is known prior
to study entry will be excluded. Patients in which EGFR mutation testing has not been
performed, or whose EGFR mutation status is unknown or inconclusive at study entry
are eligible.