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Dynamic MRI for Lung Tumor Motion and Lung Function

18 Years
Open (Enrolling)
Lung Cancer

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Trial Information

Dynamic MRI for Lung Tumor Motion and Lung Function

In this protocol, we seek to assess whether tumor motion can be inferred using dynamic MRI
and external surrogates. We propose to (1) investigate the feasibility of tracking the
real-time tumor position using dynamic MRI and inferring tumor position using external
surrogates placed on the skin of the subject and (2) determine lung function during and
following radiation by assessing lung perfusion maps obtained via dynamic MRI with dose maps
in order to determine image-based biomarkers for lung toxicity following radiation therapy.

Inclusion Criteria:

- Patients 18 years old or older

- Patients must be undergoing radiation therapy with or without chemotherapy for
thoracic and/or abdominal cancers.

Exclusion Criteria:

- Pregnant or breast-feeding women are excluded. Negative serum or urine pregnancy test
prior to study entry is required. Once on the protocol, the patient will be advised
and expected to implement an accepted and effective method of contraception such as
oral contraceptives (birthcontrol pill), intrauterine devices (IUDs), contraceptive
implants under skin or contraceptive injections and condoms with foam.

- Patients with kidney disease of any severity or on hemodialysis.

- Patients who have metallic dental fillings or other metallic implants.

- Patients with known allergies to gadolinium-based contrast agents.

- Patients who have difficulty lying flat on their back for extended periods of time
will be excluded

Type of Study:


Study Design:

Time Perspective: Prospective

Outcome Measure:

To assess whether dynamic MRI without contrast and external surrogates can be used to determine real-time lung tumor position.

Outcome Time Frame:

2 years

Safety Issue:


Principal Investigator

Warren D. D'Souza, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

UMMC MSGCC Department of Radiation Oncology


United States: Institutional Review Board

Study ID:




Start Date:

November 2009

Completion Date:

November 2014

Related Keywords:

  • Lung Cancer
  • Lung Neoplasms



Ummc MsgccBaltimore, Maryland  21201