Inclusion Criteria:

- bile duct carcinoma proven by histology in advanced or non-operable stage or tumor
extension:

1. Bismuth type III or IV ( not resectable with R0-margins )

2. Bismuth type I or II, if resective surgery is contraindicated for old age or
poor surgical risk of patient

- sufficient general condition to undergo PDT (Karnofsky status > 30%)

- age > 19 years

- access to common bile duct (either via endoscopy after sphincterotomy or
percutaneously after transhepatic drainage),

- informed written consent

Exclusion Criteria:

- porphyria or other diseases exacerbated by light

- known intolerance or allergies to porphyrin derivatives

- a planned surgical procedure within the next 30 days

- coexisting ophthalmic disease likely to require slit lamp examination within the next
30 days

- impaired kidney or liver function (creatinine > 2.5x elevated, INR > 2.2 on vitamin
K),

- leukopenia ( WBC < 2000/cmm ) or thrombopenia ( < 50000/cmm ),

- cytotoxic chemotherapy within the past 4 weeks.

- pregnancy ( and safe contraception for 6 months after PDT )

- accompanying/complicating disease with very poor prognosis (expected survival < 6
weeks),

- proven advanced peritoneal carcinomatosis ( PET scan imaging, ascites positive for
tumor cells)