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Phase III Randomized Study of Sorafenib Plus Doxorubicin Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

Phase 3
18 Years
Open (Enrolling)
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer

Thank you

Trial Information

Phase III Randomized Study of Sorafenib Plus Doxorubicin Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)


I. To compare the overall survival of patients with locally advanced or metastatic
hepatocellular carcinoma treated with sorafenib tosylate with vs without doxorubicin


I. To compare the time to progression in patients treated with these regimens. II. To
compare the progression-free-survival of patients treated with these regimens.

III. To compare the tumor response using RECIST criteria in patients treated with these

OUTLINE: This is a multicenter study. Patients are stratified according to extent of disease
(locally advanced vs metastatic). Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive doxorubicin hydrochloride IV on day 1 and oral sorafenib tosylate
twice daily on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of
disease progression or unacceptable toxicity. After 6 courses, patients may continue to
receive oral sorafenib tosylate twice daily in the absence of disease progression or
unacceptable toxicity.

ARM II: Patients receive oral sorafenib tosylate twice daily on days 1-21. Treatment repeats
every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year and
then every 6 months for 3 years.

Inclusion Criteria:

- Patients must have pathologically or cytologically proven hepatocelluar carcinoma;
Known mixed histology (e.g. hepatocellular carcinoma plus cholangiocarcinoma) or
fibrolamellar variant is not allowed

- Patients must have locally advanced or metastatic disease; Locally advanced disease
is defined as disease deemed to be unresectable or non-eligible for transplant
without distant metastases

- Lesions must be accurately measurable in at least one dimension (longest diameter to
be recorded) as >= 2 cm with conventional techniques or as >= 1 cm with spiral CT

- No prior adjuvant sorafenib or other Raf/VEGF inhibitors; Other prior adjuvant
therapy is allowed if completed >6 months prior to registration with documented
recurrence of HCC

- Patients may have been treated with loco regional therapies provided that they either

- 1) a target lesion that has not been subjected to local therapy or

- 2) the target lesion(s) within the field of the local therapy has shown an
increase of >= 20% in the size since last treatment.

- Such therapy must be completed at least 4 weeks prior to registration;
Patients that have received palliative radiation therapy to the bone need
not wait 4 weeks to begin protocol therapy

- Prior therapies allowed include the following:

- A) bland embolization, radiation, radioactive microspheres, etc

- B) chemoembolization using any chemotherapy (except, see "D", below)

- C) chemoembolization drug-eluting beads using doxorubicin

- D) prior therapy with chemoembolization using doxorubicin in the non drug
eluting beads form is NOT allowed

- No prior systemic therapy for metastatic disease

- No prior exposure to systemic doxorubicin administered intravenously

- Antiviral treatment is allowed, however interferon therapy must be stopped at least 4
weeks prior to registration

- Allografts are not allowed: No prior history of any allograft, including but not
limited to liver and bone marrow transplants

- No known CNS tumors including brain metastases

- No clinically significant gastrointestinal bleeding events requiring intervention,
transfusion, or admission to hospital within 30 days prior to registration

- Patients must have completed any major surgery >= 4 weeks from registration

- Concomitant treatment with Rifampin or St John's Wort is not allowed; Patients should
discontinue these drugs at least 4 weeks prior to registration

- Patients with a history of hypertension should be well controlled (< 140/90 mmHg) on
a regimen of anti-hypertensive therapy

- Significant history of cardiac disease is not allowed:

- Congestive heart failure > Class II New York Heart Assocation (NYHA)

- Myocardial infarction within 6 months prior to registration

- Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers
or digoxin

- Serious myocardial dysfunction, defined as scintigraphically (MUGA, myocardial
scintigram) determined absolute left ventricular ejection fraction (LVEF) below
45% or an LVEF below the normal limit at the individual institution

- No history of bleeding diathesis

- Patients receiving combination anti-retroviral therapy for human immunodeficiency
virus (HIV) are excluded from the study because of possible pharmacokinetic
interactions with sorafenib

- ECOG performance status 0-2

- Pregnancy/Nursing Status: The effects of sorafenib on the developing fetus at the
recommended therapeutic dose are unknown and may be teratogenic; Thus, women who are
pregnant should not go on study. Women should not breastfeed while participating in
this study

- Granulocytes ≥ 1,500/μL

- Hemoglobin ≥ 8.5 g/dL

- Platelets ≥ 75,000/μL

- Creatinine ≤ 1.5 times ULN OR creatinine clearance ≥ 60 mL/min

- Child-Pugh score A

- Bilirubin ≤ 3 mg/dL

- ALT and AST ≤ 5 times upper limit of normal (ULN)

- PT/INR ≤ 1.7 (Patients who are being therapeutically anticoagulated with an agent
such as coumadin or heparin will be allowed to participate provided that no prior
evidence of underlying abnormality in these parameters exists)

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Outcome Measure:

Overall survival

Outcome Description:

The confidence bound estimates for futility will also be adjusted according to the Lan-DeMets analogue of the O'Brien-Fleming boundaries.

Outcome Time Frame:

Up to 3 years

Safety Issue:


Principal Investigator

Ghassan Abou-Alfa

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer and Leukemia Group B


United States: Food and Drug Administration

Study ID:




Start Date:

February 2010

Completion Date:

Related Keywords:

  • Adult Primary Hepatocellular Carcinoma
  • Advanced Adult Primary Liver Cancer
  • Localized Unresectable Adult Primary Liver Cancer
  • Recurrent Adult Primary Liver Cancer
  • Carcinoma
  • Liver Neoplasms
  • Carcinoma, Hepatocellular



Albert Einstein College of Medicine Bronx, New York  10461
Baylor College of Medicine Houston, Texas  77030
Johns Hopkins University Baltimore, Maryland  21205
Memorial Sloan Kettering Cancer Center New York, New York  10021
University of Iowa Hospitals and Clinics Iowa City, Iowa  52242
University of Mississippi Medical Center Jackson, Mississippi  39216-4505
Washington University School of Medicine Saint Louis, Missouri  63110
Abington Memorial Hospital Abington, Pennsylvania  19001
Hurley Medical Center Flint, Michigan  48503
Sinai Hospital of Baltimore Baltimore, Maryland  21225
Genesys Hurley Cancer Institute Flint, Michigan  48503
Bronson Methodist Hospital Kalamazoo, Michigan  49007
West Michigan Cancer Center Kalamazoo, Michigan  49007-3731
Borgess Medical Center Kalamazooaa, Michigan  49001
Fairview Ridges Hospital Burnsville, Minnesota  55337
Hutchinson Area Health Care Hutchinson, Minnesota  55350
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
Avera Cancer Institute Sioux Falls, South Dakota  57105
Rapid City Regional Hospital Rapid City, South Dakota  57709
Memorial Hospital of South Bend South Bend, Indiana  46601
Mary Bird Perkins Cancer Center Baton Rouge, Louisiana  70809
Beth Israel Medical Center New York, New York  10003
New York Medical College Valhalla, New York  10595
Lehigh Valley Hospital Allentown, Pennsylvania  18103
Jackson-Madison County General Hospital Jackson, Tennessee  38301
Waukesha Memorial Hospital Waukesha, Wisconsin  53188
North Shore University Hospital Manhasset, New York  11030
Boston Medical Center Boston, Massachusetts  02118
University of Nebraska Medical Center Omaha, Nebraska  68198-3330
Kaiser Permanente Medical Center - Santa Clara Santa Clara, California  95051-5386
Via Christi Regional Medical Center Wichita, Kansas  67214
Ochsner Clinic Foundation New Orleans, Louisiana  70121
University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma  73104
Southern California Permanente Medical Group Downey, California  90242
Medical Center of Central Georgia Macon, Georgia  31201
MetroHealth Medical Center Cleveland, Ohio  44109
Long Island Jewish Medical Center New Hyde Park, New York  11040
Advocate Christ Medical Center Oak Lawn, Illinois  60453
Montefiore Medical Center Bronx, New York  10467-2490
Cancer Center of Kansas - Chanute Chanute, Kansas  66720
Cancer Center of Kansas - Dodge City Dodge City, Kansas  67801
Cancer Center of Kansas - Newton Newton, Kansas  67114
Cancer Center of Kansas - Salina Salina, Kansas  67042
Cancer Center of Kansas - Wellington Wellington, Kansas  67152
Associates in Womens Health Wichita, Kansas  67203
Cancer Center of Kansas - Winfield Winfield, Kansas  67156
Adena Regional Medical Center Chillicothe, Ohio  54601
Grady Memorial Hospital Delaware, Ohio  43015
Fairfield Medical Center Lancaster, Ohio  43130
Avera McKennan Hospital and University Health Center Sioux Falls, South Dakota  57105
Methodist Estabrook Cancer Center Omaha, Nebraska  68114-4199
Cancer Centers of the Carolinas Greenville, South Carolina  29605
Elkhart General Hospital Elkhart, Indiana  46515
South Bend Clinic South Bend, Indiana  46617
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio  43210-1240
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Alta Bates Summit Medical Center - Summit Campus Oakland, California  94609
Beebe Medical Center Lewes, Delaware  19958
Hematology and Oncology Associates Chicago, Illinois  60611
Community Cancer Center of Monroe Monroe, Michigan  48162
Great Plains Regional Medical Center North Platte, Nebraska  69101-6598
Iredell Memorial Hospital Statesville, North Carolina  28677
Bismarck Cancer Center Bismarck, North Dakota  58501
Grandview Hospital Dayton, Ohio  45405
Lima Memorial Hospital Lima, Ohio  45804
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Fulton County Health Center Wauseon, Ohio  43567
Mountainview Medical Berlin, Vermont  05602
Danville Regional Medical Center Danville, Virginia  24541
Mercy Hospital Coon Rapids, Minnesota  55433
Allenmore Hospital Tacoma, Washington  98411-0414
Hematology Oncology Associates of Illinois-Highland Park Highland Park, Illinois  60035
Ottumwa Regional Health Center Ottumwa, Iowa  52501
Bixby Medical Center Adrian, Michigan  49221
Saint Joseph Mercy Hospital Ann Arbor, Michigan  48106
Fairview-Southdale Hospital Edina, Minnesota  55435
Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Regions Hospital Saint Paul, Minnesota  55101
Saint Francis Regional Medical Center Shakopee, Minnesota  55379
Rice Memorial Hospital Willmar, Minnesota  56201
Saint Luke's Hospital Maumee, Ohio  43537
Alaska Regional Hospital Anchorage, Alaska  99508
Highland General Hospital Oakland, California  94602
Swedish American Hospital Rockford, Illinois  61104
Center for Cancer Care and Research St. Louis, Missouri  63141
Miami Valley Hospital Dayton, Ohio  45409
Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Cancer Center of Kansas - Fort Scott Fort Scott, Kansas  66701
Cancer Center of Kansas-Independence Independence, Kansas  67301
Lawrence Memorial Hospital Lawrence, Kansas  66044
Menorah Medical Center Overland Park, Kansas  66209
Shawnee Mission Medical Center Shawnee Mission, Kansas  66204
North Kansas City Hospital Kansas City, Missouri  64116
Research Medical Center Kansas City, Missouri  64132
Saint Luke's East - Lee's Summit Lee's Summit, Missouri  64086
Liberty Hospital Liberty, Missouri  64068
Heartland Regional Medical Center Saint Joseph, Missouri  64506
Mary Rutan Hospital Bellefontaine, Ohio  43311
Wayne Hospital Greenville, Ohio  45331
Knox Community Hospital Mount Vernon, Ohio  43050
Fisher-Titus Medical Center Norwalk, Ohio  44857
Clinton Memorial Hospital Wilmington, Ohio  45177
Providence Centralia Hospital Centralia, Washington  98531-9027
Genesys Regional Medical Center Grand Blanc, Michigan  48439-8066
Ben Taub General Hospital Houston, Texas  77030
Methodist Hospital Houston, Texas  77030
Greene Memorial Hospital Xenia, Ohio  45385
Greater Baltimore Medical Center Baltimore, Maryland  21204
Rutherford Hospital Rutherfordton, North Carolina  28139
AnMed Health Cancer Center Anderson, South Carolina  29621
Union Hospital of Cecil County Elkton MD, Maryland  21921
Cancer Centers of the Carolinas - Grove Commons Greenville, South Carolina  29605
Cancer Centers of the Carolinas - Seneca Seneca, South Carolina  29672
Cancer Centers of the Carolinas - Spartanburg Spartanburg, South Carolina  29307
Presbyterian Hospital Charlotte, North Carolina  28233-3549
Phelps County Regional Medical Center Rolla, Missouri  65401
Saint Francis Medical Center Grand Island, Nebraska  68802
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee  37662
La Grange Memorial Hospital La Grange, Illinois  60525
Queen's Medical Center Honolulu, Hawaii  96813
University of Alabama at Birmingham Birmingham, Alabama  35294-3300
Providence Hospital Mobile, Alabama  36608
Meharry Medical College Nashville, Tennessee  37208-3599
Providence Medical Center Kansas City, Kansas  66112
Northwestern University Chicago, Illinois  60611
East Bay Radiation Oncology Center Castro Valley, California  94546
Contra Costa Regional Medical Center Martinez, California  94553-3156
Larry G Strieff MD Medical Corporation Oakland, California  94609
Kapiolani Medical Center at Pali Momi Aiea, Hawaii  96701
Kapiolani Medical Center for Women and Children Honolulu, Hawaii  96826
Maui Memorial Medical Center Wailuku, Hawaii  96793
Hennepin County Medical Center Minneapolis, Minnesota  
University of Rochester Rochester, New York  14642
Glens Falls Hospital Glens Falls, New York  12801
Saint Alphonsus Regional Medical Center Boise, Idaho  83706
El Camino Hospital Mountain View, California  94040
Yale University New Haven, Connecticut  06520
Kaiser Permanente Medical Center Vallejo, California  94589
Straub Clinic and Hospital Honolulu, Hawaii  96813
Lakeland Regional Cancer Center Lakeland, Florida  33805
Riverside Methodist Hospital Columbus, Ohio  43214
Licking Memorial Hospital Newark, Ohio  43055-2899
Cancer Center of Kansas - McPherson McPherson, Kansas  67460
Saint Mary's Regional Medical Center Reno, Nevada  89503
Dartmouth Hitchcock Medical Center Lebanon, New Hampshire  03756
Mid Dakota Clinic Bismarck, North Dakota  58501
Columbus CCOP Columbus, Ohio  43206
University Of Vermont Burlington,, Vermont  05403
Sacred Heart Hospital Pensacola, Florida  32503
Kaiser Permanente Sacramento, California  
University of Kentucky Lexington, Kentucky  40536-0098
Wichita CCOP Wichita, Kansas  67214-3882
Flower Hospital Sylvania, Ohio  43560-2197
Metro-Minnesota CCOP St. Louis Park, Minnesota  
Providence Hospital Southfield, Michigan  48075
Cancer Centers of the Carolinas - Easley Easley, South Carolina  29640
Lakeview Hospital Stillwater, Minnesota  55082
Tulane University Health Sciences Center New Orleans, Louisiana  70112
Louisiana State University Health Science Center New Orleans, Louisiana  70112
Kaiser Permanente Portland, Oregon  97227
Florida Hospital Orlando, Florida  32803
Memorial Health University Medical Center Savannah, Georgia  31404
University of Chicago Comprehensive Cancer Center Chicago, Illinois  60637-1470
Northern Indiana Cancer Research Consortium South Bend, Indiana  
Rockwood Clinic Spokane, Washington  99220
Hawaii Medical Center East Honolulu, Hawaii  96817
Valley View Hospital Cancer Center Glenwood Springs, Colorado  81601
Southeast Cancer Center Cape Girardeau, Missouri  63703
Butler Memorial Hospital Butler, Pennsylvania  16001
New Ulm Medical Center New Ulm, Minnesota  56073
Valley Medical Oncology Consultants-Castro Valley Castro Valley, California  94546
Valley Medical Oncology Consultants-Fremont Fremont, California  94538
Kaiser Permanente, Fremont Fremont, California  94538
Kaiser Permanente, Hayward Hayward, California  94545
Bay Area Breast Surgeons Inc Oakland, California  94609
Bay Area Tumor Institution CCOP Oakland, California  94609
Tom K Lee Inc Oakland, California  94609
Kaiser Permanente-Oakland Oakland, California  94611
Kaiser Permanente-Redwood City Redwood City, California  94063
Kaiser Permanente-Richmond Richmond, California  94801
Kaiser Permanente-Roseville Roseville, California  95661
Kaiser Permanente-South Sacramento Sacramento, California  95823
Kaiser Permanente - Sacramento Sacramento, California  95825
Kaiser Permanente-San Francisco San Francisco, California  94115
University of California San Francisco Medical Center-Mount Zion San Francisco, California  94115
Kaiser Permanente-Santa Teresa-San Jose San Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer Center San Pablo, California  94806
Kaiser Permanente-San Rafael San Rafael, California  94903
Kaiser Permanente-Santa Rosa Santa Rosa, California  95403
Kaiser Permanente-South San Francisco South San Francisco, California  94080
Kaiser Permanente-Stockton Stockton, California  95210
Kaiser Permanente-Vallejo Vallejo, California  94589
Kaiser Permanente-Walnut Creek Walnut Creek, California  94596
Saint Mary's Hospital and Regional Medical Center Grand Junction, Colorado  81502
Saint Francis Hospital and Medical Center Hartford, Connecticut  06105
Middlesex Hospital Middletown, Connecticut  06457
Lombardi Comprehensive Cancer Center at Georgetown University Washington, District of Columbia  20057
Sacred Heart Medical Oncology Group - Davis Highway Pensacola, Florida  32514
Veterans Administration Medical Center Decatur, Georgia  30033
Saint Joseph's-Candler Health System Savannah, Georgia  31405
Oncare Hawaii Inc-POB II Honolulu, Hawaii  96813
Oncare Hawaii Inc-Kuakini Honolulu, Hawaii  96817
University of Hawaii Honolulu, Hawaii  96813
Pacific Cancer Institute of Maui Wailuku, Hawaii  96793
Rush - Copley Medical Center Aurora, Illinois  60504
Joliet Oncology-Hematology Associates Limited Joliet, Illinois  60435
Midwest Center for Hematology Oncology Joliet, Illinois  60432
Provena Saint Mary's Hospital Kankakee, Illinois  60901
North Shore Hematology Oncology Libertyville, Illinois  60048
Hematology Oncology Associates of Illinois - Skokie Skokie, Illinois  60076
Saint Francis Hospital and Health Centers Beech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State Boulevard Fort Wayne, Indiana  46845
Saint Anthony Memorial Health Center Michigan City, Indiana  46360
Reid Hospital and Health Care Services Richmond, Indiana  47374
McFarland Clinic Ames, Iowa  50010
Hematology Oncology Associates-Quad Cities Bettendorf, Iowa  52722
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Cancer Center of Kansas - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas-Kingman Kingman, Kansas  67068
Cancer Center of Kansas - Parsons Parsons, Kansas  67357
Cancer Center of Kansas - Pratt Pratt, Kansas  67124
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas - Main Office Wichita, Kansas  67214
Ochsner Clinic Foundation-Baton Rouge Baton Rouge, Louisiana  70809
Medical Center of Louisiana New Orleans, Louisiana  70112
Ochsner Clinic CCOP New Orleans, Louisiana  70121
Hickman Cancer Center Adrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor, Michigan  48106
Oakwood Hospital Dearborn, Michigan  48123
Saint John Hospital and Medical Center Detroit, Michigan  48236
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Allegiance Health Jackson, Michigan  49201
Sparrow Hospital Lansing, Michigan  48912
Saint Mary Mercy Hospital Livonia, Michigan  48154
Mercy Memorial Hospital Monroe, Michigan  48162
Saint Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Saint Joseph Mercy Port Huron Port Huron, Michigan  48060
Saint Mary's of Michigan Saginaw, Michigan  48601
Lakeland Hospital St. Joseph, Michigan  49085
Saint John Macomb-Oakland Hospital Warren, Michigan  48093
Miller-Dwan Hospital Duluth, Minnesota  55805
Unity Hospital Fridley, Minnesota  55432
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
Minneapolis Veterans Medical Center Minneapolis, Minnesota  55417
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Saint Luke's Cancer Institute Kansas City, Missouri  64111
Saint Luke's Hospital of Kansas City Kansas City, Missouri  64111
Saint Joseph Health Center Kansas City, Missouri  64114
Liberty Radiation Oncology Clinic Kansas City, Missouri  64116
Truman Medical Center Kansas City, Missouri  64108
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Cox Medical Center Springfield, Missouri  65807
Nevada Cancer Research Foundation CCOP Las Vegas, Nevada  89106
Cooper Hospital University Medical Center Camden, New Jersey  08103
Veterans Adminstration New Jersey Health Care System East Orange, New Jersey  07018-1095
Veterans Affairs Western New York Health Care System-Buffalo Buffalo, New York  14215
Orange Regional Medical Center Middletown, New York  10940
Saint Luke's Roosevelt Hospital Center - Saint Luke's Division New York, New York  10025
Columbia University Medical Center New York, New York  10032
State University of New York Upstate Medical University Syracuse, New York  13210
Mission Hospitals Inc Asheville, North Carolina  28801
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Kinston Medical Specialists PA Kinston, North Carolina  28501
Saint Alexius Medical Center Bismarck, North Dakota  58501
Summa Barberton Hospital Barberton, Ohio  44203
Aultman Health Foundation Canton, Ohio  44710
Doctors Hospital Columbus, Ohio  43228
Grant Medical Center Columbus, Ohio  43215
Mount Carmel Health Center West Columbus, Ohio  43222
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Veteran Affairs Medical Center Dayton, Ohio  45428
Hematology Oncology Center Incorporated Elyria, Ohio  44035
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Kettering Medical Center Kettering, Ohio  45429
Saint Rita's Medical Center Lima, Ohio  45801
Marietta Memorial Hospital Marietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio  43537
Saint Charles Hospital Oregon, Ohio  43616
North Coast Cancer Care Sandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOP Toledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy Hospital Toledo, Ohio  43623
University of Toledo Toledo, Ohio  43614
Saint Vincent Mercy Medical Center Toledo, Ohio  43608
Upper Valley Medical Center Troy, Ohio  45373
Saint Ann's Hospital Westerville, Ohio  43081
Genesis HealthCare System Zanesville, Ohio  43701
AnMed Health Hospital Anderson, South Carolina  29621
Greenville CCOP Greenville, South Carolina  29615
Greenville Memorial Hospital Greenville, South Carolina  29605
Upstate Carolina CCOP Spartanburg, South Carolina  29303
Veterans Administration Medical Center Houston, Texas  77030
Saint Luke's Episcopal Hospital Houston, Texas  77030
Fredericksburg Oncology Inc Fredericksburg, Virginia  22401
Southwest VA Regional Cancer Center Norton, Virginia  24273
Auburn Regional Medical Center Auburn, Washington  98002
Saint Francis Hospital Federal Way, Washington  98003
Providence - Saint Peter Hospital Olympia, Washington  98506-5166
Good Samaritan Community Hospital Puyallup, Washington  98372
Northwest CCOP Tacoma, Washington  98405
Multicare Health System Tacoma, Washington  98415
Saint Clare Hospital Tacoma, Washington  98499
Saint Joseph Medical Center Tacoma, Washington  98405
Langlade Hospital and Cancer Center Antigo, Wisconsin  54409
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Bay Area Medical Center Marinette, Wisconsin  54143
Oconomowoc Memorial Hospital-ProHealth Care Inc Oconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Aspirus Regional Cancer Center Wausau, Wisconsin  54401
University of California Medical Center At Irvine-Orange Campus Orange, California  92868
University of Maryland Greenebaum Cancer Center Baltimore, Maryland  21201
University of Illinois Chicago, Illinois  60612
Stony Brook University Medical Center Stony Brook, New York  11794
York Hospital York, Maine  03909
Elkhart Clinic Elkhart, Indiana  46515
University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado  80045
Montrose Memorial Hospital Montrose, Colorado  81401
Michiana Hematology Oncology PC-Elkhart Elkhart, Indiana  46514
Michiana Hematology Oncology PC-Plymouth Plymouth, Indiana  46563
Michiana Hematology Oncology PC-South Bend South Bend, Indiana  46601
Michiana Hematology Oncology-PC Westville Westville, Indiana  46391
Cancer Center of Kansas-Liberal Liberal, Kansas  67901
Saint Agnes Hospital Baltimore, Maryland  21229
Michiana Hematology Oncology PC-Niles Niles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer Center Bolivar, Missouri  65613
Skaggs Cancer Center Branson, Missouri  65616
University of Missouri - Ellis Fischel Columbia, Missouri  65203
Veterans Administration Columbia, Missouri  65201
Renown Regional Medical Center Reno, Nevada  89502
UMDNJ - New Jersey Medical School Newark, New Jersey  07103
North Coast Cancer Care-Clyde Clyde, Ohio  43410
Community Health Partners Regional Medical Center Elyria, Ohio  44035
Cancer Centers of the Carolinas - Faris Greenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer, South Carolina  29650
Cancer Centers of the Carolinas-Greer Medical Oncology Greer, South Carolina  29650
University of Tennessee - Knoxville Knoxville, Tennessee  37920
Nashville Oncology Associates PC Nashville, Tennessee  37203
Holy Family Memorial Hospital Manitowoc, Wisconsin  54221
VA Pittsburgh Healthcare System Pittsburgh, Pennsylvania  15240
Monter Cancer Center Lake Success, New York  11042
Kaiser Permanente Los Angeles Medical Center Los Angeles, California  90027
Kaiser Anaheim Medical Center Anaheim, California  92807
Kaiser Permanente-Deer Valley Medical Center Antioch, California  94531
Kaiser Permanente Medical Group - Baldwin Park Baldwin Park, California  91706
Kaiser Foundation Hospital Bellflower, California  90706
Kaiser Permanente Hospital Fontana, California  92335
Kaiser Permanente - Harbor City Harbor City, California  90710
Kaiser Permanente-West Los Angeles Los Angeles, California  90034
Epic Care-Oakland Oakland, California  94612
Kaiser Permanente - Panorama City Panorama City, California  91402
Salinas Valley Memorial Salinas, California  93901
Kaiser Permanente at San Diego San Diego, California  92120
Kaiser Permanente Health Care San Marcos, California  92069
Kaiser Permanente Medical Center-Vacaville Vacaville, California  95688
Kaiser Permanente-Rock Creek Lafayette, Colorado  80026
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii  96819
Saint Joseph Regional Medical Center Lewiston, Idaho  83501
Saint Luke's South Hospital Overland Park, Kansas  66213
Kansas City CCOP Prairie Village, Kansas  66208
Doctors Carrol, Sheth, Raghavan Louisville, Kentucky  40215
Hematology and Oncology Clinic Baton Rouge, Louisiana  70809
Ochsner North Shore Medical Center Covington, Louisiana  70433
Capital Region Medical Center-Goldschmidt Cancer Center Jefferson City, Missouri  65109
Heartland Hematology and Oncology Associates Incorporated Kansas City, Missouri  64118
Saint Joseph Oncology Inc Saint Joseph, Missouri  64507
Comprehensive Cancer Care PC Saint Louis, Missouri  63141
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus Brooklyn, New York  11209
Mount Carmel East Hospital Columbus, Ohio  43213
The Mark H Zangmeister Center Columbus, Ohio  43219
Southern Ohio Medical Center Portsmouth, Ohio  45662
Cancer Care Associates-Mercy Oklahoma City, Oklahoma  73120
Saint Francis Hospital Greenville, South Carolina  29601
Memorial Hospital Of Martinsville Martinsville, Virginia  24115
Overlake Hospital Medical Center Bellevue, Washington  98004
Providence Regional Cancer Partnership Everett, Washington  98201
Gundersen Lutheran La Crosse, Wisconsin  54601
Saint Nicholas Hospital Madison, Wisconsin  53715
Kaiser Permanente-Franklin Denver, Colorado  80205
Siouxland Hematology Oncology Associates Sioux City, Iowa  51101
Walter Reed National Military Medical Center Bethesda, Maryland  20889
Roger Williams Hospital Providence, Rhode Island  02908
VA Medical Center - University of Iowa Iowa City, Iowa  52246
Carle Foundation - Carle Cancer Center Urbana, Illinois  61801
Michiana Hematology Oncology PC-Mishawaka Mishawaka, Indiana  46545-1470
Marie Yeager Cancer Center Saint Joseph, Michigan  49085
Hematology Oncology Associates of Central New York PC East Syracuse, New York  13057
Summa Akron City Hospital Akron, Ohio  44304
Franciscan St. Francis Health Indianapolis, Indiana  46237
The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio  43606
North Shore-LIJ Health System CCOP Manhasset, New York  11030
Genesys Regional Medical Center-West Flint Campus Flint, Michigan  48532
Essentia Health Saint Joseph's Medical Center Brainerd, Minnesota  56401
Essentia Health Duluth Clinic CCOP Duluth, Minnesota  55805
Essentia Health Saint Mary's Medical Center Duluth, Minnesota  55805
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Toledo Clinic Cancer Centers-Oregon Oregon, Ohio  43616
Presbyterian Intercommunity Hospital Whittier, California  90602
Community Howard Regional Health Kokomo, Indiana  46904
Indiana University Health La Porte Hospital La Porte, Indiana  46350
Saint Joseph Regional Medical Center-Mishawaka Mishawaka, Indiana  46545-1470
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota  58103
Christiana Care Health System-Christiana Hospital Newark, Delaware  19718
Illinois Cancer Specialists-Niles Niles, Illinois  60714
Springfield Regional Medical Center Springfield, Ohio  45505
Toledo Clinic Cancer Centers-Bowling Green Bowling Green, Ohio  43402
Toledo Clinic Cancer Centers-Maumee Maumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-Toledo Toledo, Ohio  43623
Guthrie Clinic-Robert Packer Hospital Sayre, Pennsylvania  18840
Self Regional Healthcare Greenwood, South Carolina  29646
NEA Baptist Clinic-Matthews Jonesboro, Arkansas  72401
Cancer Care Associates-Norman Norman, Oklahoma  73071
Mercy Physicians of Oklahoma-Lakeside Oklahoma City, Oklahoma  73120
Cancer Center of Western Wisconsin New Richmond, Wisconsin  54017
East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill Pleasant Hill, California  94523
D N Greenwald Center Mukwonago, Wisconsin  53149
Epic Care-Dublin Dublin, California  94568
Veterans Affairs Medical Center -Washington DC Washington, District of Columbia  20422
Bronx Veterans Administration Medical Center Bronx, New York  10468
White River Junction Veteran Administration Medical Center White River Junction, Vermont  05009