Inclusion Criteria:

- NHL histological diagnosis of diffuse large B cell CD20 + (de novo or shift from
low-grade NHL if not pretreated), grade IIIb follicular NHL;

- Age >= 18 years;

- Presence of at least 1 factor that defines the cardiopathy;

- Life expectancy > 3 months;

- In the case of women of childbearing age absence of pregnancy at the beginning of the
chemotherapy;

- Written informed consent.

Exclusion Criteria:

- Histology different from NHL diffuse large cell CD20 + or follicular IIIb

- Age < 18 years

- Inability to sign informed consent;

- HIV positivity;

- Patients HBsAg positive;

- AST/ALT > 2 times the standard;

- Bilirubin > 2 times the standard;

- Creatinine > 2.5 mg / dl;

- Location of CNS disease;

- Pregnancy ongoing;

- Damage to that organ or medical problems that could interfere with the therapy;

- Current uncontrolled infection;

- Senile dementia