Inclusion Criteria:

- All patients undergoing radical cystectomy for bladder cancer who are considered
candidates for a neobladder reconstruction are eligible for enrollment.

- Diagnosed with primary bladder cancer (any histology).

- Scheduled to undergo a radical cystectomy (cystoprostatectomy in men and anterior
exenteration in women).

- Felt by the treating physician to be a candidate for an orthotopic neobladder urinary
diversion.

- Be competent and willing to sign the informed consent.

- Patients may have received previous radiation therapy or intravesical or systemic
chemotherapy. Patients with documented metastatic disease are not excluded as long as
they are felt to be candidates for a continent neobladder urinary diversion.

Exclusion Criteria:

- Patients undergoing radical cystectomy for any malignancy other than primary bladder
cancer (for example prostate cancer or colon cancer invading the bladder,or a
gynecologic malignancy), or non-malignant disease (such as a neurogenic bladder or
radiation cystitis).

- Unwilling or unable to sign the informed consent.

- Not eligible for an orthotopic neobladder reconstruction.

- A history of other malignancy (except for stage I cancer treated with curative intent
without evidence of recurrence, clinically localized prostate cancer either untreated
or treated with prostatectomy or radiation therapy or hormone therapy,or non-melanoma
skin cancer) within the previous 5 years.