Trial Information
Cross-Over Broccoli Sprouts Trial - Qidong
Inclusion Criteria:
- Adults aged 25-65 in good general health with no history of a chronic illness
- normal liver function tests (ALT, AST, bilirubin)
- normal renal function tests (creatinine, BUN, urinalysis)
- serum alpha-fetoprotein negative
Exclusion Criteria:
- personal history of cancer, except for non-melanoma skin cancer
- use of prescribed medications
- hepatomegaly by clinical exam
- unwillingness to avoid cruciferous vegetable consumption for the duration of the
study
- for women, a positive pregnancy test.
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
Outcome Measure:
Urinary levels of glucoraphanin or sulforaphane and metabolites.
Outcome Time Frame:
Endpoints will be assessed on urine samples collected daily during the intervention.
Safety Issue:
No
Principal Investigator
Thomas W Kensler, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Johns Hopkins School of Public Health
Authority:
United States: Institutional Review Board
Study ID:
IRB00002015
NCT ID:
NCT01008826
Start Date:
October 2009
Completion Date:
December 2009
Related Keywords:
- Healthy
- sulforaphane
- pharmacokinetics