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Cross-Over Broccoli Sprouts Trial - Qidong


Phase 1
25 Years
65 Years
Not Enrolling
Both
Healthy

Thank you

Trial Information

Cross-Over Broccoli Sprouts Trial - Qidong


Inclusion Criteria:



- Adults aged 25-65 in good general health with no history of a chronic illness

- normal liver function tests (ALT, AST, bilirubin)

- normal renal function tests (creatinine, BUN, urinalysis)

- serum alpha-fetoprotein negative

Exclusion Criteria:

- personal history of cancer, except for non-melanoma skin cancer

- use of prescribed medications

- hepatomegaly by clinical exam

- unwillingness to avoid cruciferous vegetable consumption for the duration of the
study

- for women, a positive pregnancy test.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Outcome Measure:

Urinary levels of glucoraphanin or sulforaphane and metabolites.

Outcome Time Frame:

Endpoints will be assessed on urine samples collected daily during the intervention.

Safety Issue:

No

Principal Investigator

Thomas W Kensler, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Johns Hopkins School of Public Health

Authority:

United States: Institutional Review Board

Study ID:

IRB00002015

NCT ID:

NCT01008826

Start Date:

October 2009

Completion Date:

December 2009

Related Keywords:

  • Healthy
  • sulforaphane
  • pharmacokinetics

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