Inclusion Criteria:

- Adults > 18 years old, holder of up to 3 nodules less than 4 cm in diameter

- Diagnosis of hepatocellular carcinoma according to American Society of Liver Study
non invasive criteria or based on histological proof

- Non invasive diagnosis of cirrhosis according to French Haute Authority of illness
guideline or based on histological proof

- No previous treatment for hepatocellular carcinoma

- Multidisciplinary decision of treatment by radiofrequency ablation

Exclusion Criteria:

- Adult patient under guardianship or trusteeship, homeless

- Patient with potentially short term life-threatening serious co-infection (apart from
viral B or C, or VIH co-infection)

- Pregnant or breastfeeding woman

- Patient for whom regular follow-up is impossible whatever the cause

- Contra indication to general anaesthesia

- Technical impossibility to perform the procedure under ultrasound guidance

- Boundary of the tumor located at less than 1 cm distance from colonic wall or main
biliary tract (main right or left bill ducts and common bill duct)

- Tumor invisible with ultrasound

- Lack of safe percutaneous course which can be planned

- Tumor in which more than four biopsies pass were previously performed (cumulated
during one or several previous biopsies sessions)

- Contra indication to perform CT or MRI with contrast medium (GADOLINITE or iodinate)
intravenous injection

- Child-Pugh B or C cirrhosis (apart from the transitory liver failures in the setting
of acute hepatitis related to alcohol abuse)

- Total detachment of the anterior face of the liver from internal abdominal wall due
to abundant ascites.

- Prothrombin activity < 50 %

- Platelet count <40 .10 3/ml

- Platelet dysfunction or congenital impaired blood coagulating