Trial Information

N-acetyl Cysteine Plus Clomiphene Citrate Versus Metformin and Clomiphene Citrate in Treatment of Clomiphene-resistant Polycystic Ovary Syndrome

In combined NAC-CC group group,patients received NAC (200 mg per sachet, SEDICO, Egypt) for
5-6 weeks from the 1st day of of spontaneous or induced menstruation (in a dose of 1.8 g
orally in three divided doses, 3 sachets per dose). All patients in other group received
metformin HCl (Cidophage®; Chemical Industries Development, Egypt), 500 mg thrice daily for
5-6 weeks from the 1st day of spontaneous or induced menstruation. Then after the end of
this period, patients in either group received 100 mg CC (Clomid®; Global Napi
Pharmaceuticals,Cairo, Egypt) for 5 days starting from day 3 of spontaneous or induced
menstruation. With persistent anovulation, it was increased by 50 mg for the next cycle.
Patients continued treatment for three successive cycles using the same protocol. NAC and
metformin were stopped only when pregnancy was documented.