Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, Taiwan
18 Years
N/A
Both
Non Small Cell Lung Cancer
Trial Information
Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taipei, Taiwan
We have been following a schedule of weekly low dose docetaxel (30 mg/m2 on days 1 and 8
every 3 weeks; 60 mg/m2 accumulated dose for each cycle) at our hospital in an effort to
achieve better tolerability. We therefore performed an exploratory study, by statistical
analyses, to investigate the efficacy and toxicity of such a low dose docetaxel schedule
compared to that of pemetrexed in patients with NSCLC who have failed previous chemotherapy.
Inclusion Criteria:
- stage IIIb or IV NSCLC
- previous treatment with chemotherapy or tyrosin kinase inhibitor
- performance status less than 2
Exclusion Criteria:
- age less 18 years
- pregnancy
- performance status 3-4
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Objective response rate
Outcome Time Frame:
at least 3 cycles
Safety Issue:
Yes
Principal Investigator
Han-Pin Kuo
Investigator Role:
Principal Investigator
Investigator Affiliation:
Chang Gung Memorial Hospital
Authority:
Taiwan: Institutional Review Board
Study ID:
98-2587B
NCT ID:
NCT01004601
Start Date:
March 2005
Completion Date:
October 2008
Related Keywords:
- Non Small Cell Lung Cancer
- pretreated failure advanced stage IIIb/IV NSCLC
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
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