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Diagnostic and Prognostic Markers in Low-Grade Gliomas


N/A
N/A
N/A
Open (Enrolling)
Both
Brain and Central Nervous System Tumors

Thank you

Trial Information

Diagnostic and Prognostic Markers in Low-Grade Gliomas


OBJECTIVES:

- Evaluate the diagnostic and prognostic relevance of alterations of specific chromosomes
and chromosomal regions including 7, 9p, 10p, 10q, 13q, 17p, 17q, 19q, 22q, X, and Y,
using PCR analysis of microsatellite repeats and FISH.

- Evaluate the diagnostic and prognostic relevance of DNA ploidy by flow cytometric
analysis; compare with ploidy determination by FISH.

- Assess the diagnostic and prognostic relevance of various markers of cellular
proliferation and cellular function including flow cytometric determination of
%S-phase, %G2M, and immunohistochemical evaluation of PCNA, Ki-67, and p53.

OUTLINE: Previously preserved paraffin-embedded tissue blocks are obtained and used for
biomarker studies. Blood samples obtained during treatment are also obtained. Loss of
heterozygosity of specific chromosomal regions are performed using PCR analysis of
microsatellite repeats (41,118-120) on DNA extracted from the paraffin-embedded archival
specimens. FISH and flow cytometry may also be used to assess chromosomal loss of deletion.
Immunohistochemistry is also performed.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of low-grade glioma, meeting 1 of the following criteria:

- Paraffin embedded tumor tissue blocks obtained while enrolled in prospective
NCCTG and Mayo studies available

- Paraffin-embedded tumor tissue blocks obtained while enrolled in NCCTG 86-72-51
or NCCTG 93-72-02 available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Alterations of specific chromosomes and chromosomal regions including 7, 9p, 10p, 10q, 13q, 17p, 17q, 19q, 22q, X, and Y, using PCR analysis of microsatellite repeats and FISH

Safety Issue:

No

Principal Investigator

Jan C. Buckner, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Mayo Clinic

Authority:

Unspecified

Study ID:

CDR0000406626

NCT ID:

NCT01004523

Start Date:

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • childhood low-grade cerebellar astrocytoma
  • childhood low-grade cerebral astrocytoma
  • childhood mixed glioma
  • adult mixed glioma
  • adult diffuse astrocytoma
  • childhood oligodendroglioma
  • adult oligodendroglioma
  • Glioma
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms

Name

Location
Mayo Clinic Scottsdale Scottsdale, Arizona  85259
Mayo Clinic - Jacksonville Jacksonville, Florida  32224
Mayo Clinic Cancer Center Rochester, Minnesota  55905
CCOP - Iowa Oncology Research Association Des Moines, Iowa  50309-1016
MeritCare Bemidji Bemidji, Minnesota  56601
CCOP - Duluth Duluth, Minnesota  55805
Miller - Dwan Medical Center Duluth, Minnesota  55805
MeritCare Broadway Fargo, North Dakota  58122
CCOP - MeritCare Hospital Fargo, North Dakota  58122
Rapid City Regional Hospital Rapid City, South Dakota  57709
John Stoddard Cancer Center at Iowa Methodist Medical Center Des Moines, Iowa  50309
St. Vincent Mercy Medical Center Toledo, Ohio  43608
CCOP - Toledo Community Hospital Toledo, Ohio  43623-3456
Medical University of Ohio Cancer Center Toledo, Ohio  43614
Toledo Hospital Toledo, Ohio  43606
John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Des Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates - West Des Moines West Des Moines, Iowa  50266
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
Community Cancer Center of Monroe Monroe, Michigan  48162
Wood County Oncology Center Bowling Green, Ohio  43402
Lima Memorial Hospital Lima, Ohio  45804
Northwest Ohio Oncology Center Maumee, Ohio  43537
Toledo Clinic - Oregon Oregon, Ohio  43616
St. Charles Mercy Hospital Oregon, Ohio  43616
Mercy Hospital of Tiffin Tiffin, Ohio  44883
Toledo Clinic, Incorporated - Main Clinic Toledo, Ohio  43623
Fulton County Health Center Wauseon, Ohio  43567
Mercy Memorial Hospital - Monroe Monroe, Michigan  48162
Hematology Oncology Center Elyria, Ohio  44035
Community Cancer Center Elyria, Ohio  44035
Flower Hospital Cancer Center Sylvania, Ohio  43560
St. Anne Mercy Hospital Toledo, Ohio  43623
Fredericksburg Oncology, Incorporated Fredericksburg, Virginia  22401
St. Alexius Medical Center Cancer Center Bismarck, North Dakota  58502
Essentia Health - Duluth Clinic Duluth, Minnesota  55805-1983