Inclusion Criteria:

- Histologically documented non-small cell lung cancer, Stages 3B, 4 or recurrent

- Pleural effusion cytologically proven to be malignant

- 0 or 1 prior chemotherapy regimens for non-small cell lung cancer (adjuvant
chemotherapy post resection, or concurrent chemo-radiation therapy counts as one
regimen regardless of number of agents used.)

- Planning to start chemotherapy for non-small cell lung cancer (treatment regimen at
discretion of treating physician but must include one or more of the following
agents:cisplatin,carboplatin,docetaxel,paclitaxel,
pemetrexed,gemcitabine,vinorelbine) Patients may receive anti-angiogenesis agents
(bevacizumab) in addition to chemotherapy, but patients treated solely with tyrosine
kinase inhibitors or growth-factor receptor blockers are not eligible.

- Prior radiation therapy is permitted.

- Performance status 0,1,2

- Serum creatinine less than 2.0 or estimated creatinine clearance over 30cc/min by
Calcroft/Gault equation

- Estimated life expectancy over 3 months

- Signed informed consent

- Age greater than 18 years

- Patients who have clinical indication for Zometa treatment such as lytic bone
metastases or hypercalcemia can be included

Exclusion Criteria:

- Pregnant or lactating

- Patient with concurrent medical or psychiatric illness which would, in the opinion of
the investigator, prevent compliance with the study

- Patients who undergo any procedure other than thoracentesis for drainage of
effusion.Patients may have had more than one thoracentesis prior to study. Patients
who have large bore chest tube placement, permanent transthoracic catheter (Pleurex),
medical pleurodesis or thoracoscopy are excluded.

- Current active dental problems including infection of the teeth or jawbone (maxilla
or mandibular);dental or fixture trauma, or a current or prior diagnosis of
osteonecrosis of the jaw (ONJ), of exposed bone in the mouth, or of slow healing
after dental procedures.

- Recent (within 6 weeks)or planned dental or jaw surgery (e.g.extraction, implants).