Inclusion Criteria:

- Histological or cytological diagnosis of nonsquamous Stage IIIB or Stage IV NSCLC
that is not amenable to curative therapy.

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1

- At least 1 unidimensionally measurable lesion meeting the Response Evaluation
Criteria In Solid Tumors (RECIST) criteria.

- Adequate organ function, including the following:

- Adequate bone marrow reserve: absolute neutrophil (segmented and bands) count
(ANC) >1.5 x 109/L, platelets >100 x 10^9/L, and hemoglobin > 10 g/dL.

- Hepatic: bilirubin <1.5 times the upper limit of normal (ULN);alkaline
phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase
(ALT) <3.0 x ULN (AP, AST, and ALT <5 x ULN is acceptable if liver has tumor
involvement).

- Renal: calculated creatinine clearance (CrCl) >45 mL/min based on the original
weight-based Cockcroft and Gault formula, and serum creatinine <1.5 x ULN.

- At the time of enrollment, if the urinalysis dipstick result is >2+ for protein,
a 24-hour urine collection should be taken. In these cases, participants must
have <1g protein/24 hours to be eligible for study participation.

- Participants must sign an Informed Consent Document (ICD).

Exclusion Criteria:

- Have received prior systemic anticancer therapy for lung cancer (including adjuvant
early-stage treatment for NSCLC).

- Have a serious cardiac condition, such as myocardial infarction within 6 months,
angina, or heart disease, as defined by the New York Heart Association Class III or
IV.

- Have a second primary malignancy that is clinically detectable at the time of
consideration for study enrollment.

- Are receiving concurrent administration of any other antitumor therapy.

- Have a history of gastrointestinal fistula, perforation, or abscess, inflammatory
bowel disease, or diverticulitis.

- Have had significant weight loss (that is, >10%) over the previous 6 weeks before
study entry.

- Have a history of gross hemoptysis (bright red blood of >½ teaspoon per episode of
coughing) <3 months prior to enrollment or history or evidence of inherited bleeding
diathesis or coagulopathy with the risk of bleeding.

- Are taking or have recently taken (within 10 days of enrollment) full-dose oral or
parenteral anticoagulants or thrombolytic agents for therapeutic purposes.
Prophylactic use of anticoagulants is allowed; international normalized ratio (INR)
should be <1.5 at study enrollment.

- Have a history of hypertension, unless hypertension is well controlled upon study
entry (<150/90 mm Hg) and the participant is on a stable regimen of antihypertensive
therapy. Participants should not have any prior history of hypertensive crisis or
hypertensive encephalopathy.

- Have had major surgery, open biopsy, or significant traumatic injury within 28 days
prior to study enrollment, or anticipate the need for major surgical procedure during
the course of the study.

- History of thrombotic disorders within the last 6 months prior to entry.