Inclusion Criteria:

- All patients must be older than 18 years of age and female patients who are pregnant,
breast feeding or not on adequate contraceptive measures will be excluded.

- All patients will provide a written informed consent prior to the study.

- Consecutive patients from 2 centers in Liguria (National Institute for Cancer
Research - Genova and Centro Urologico di Eccellenza ASL 1 - Imperia) with overt or
suspected non muscle invasive bladder cancer, including Cis detected by mean of
random biopsies or a positive urinary cytology, will be included in the study and
randomized to 2 treatments A, B arms.

Exclusion Criteria:

- Patients with muscle invasive bladder cancer will be excluded.

- Patients submitted to immediate radical cystectomy after transurethral resection,
irrespective of the clinical stage, will be excluded.