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Molecular and Genetic Analysis of Disturbed Wound Healing in Barbadians With Diabetic Foot Ulcers

Not Enrolling
Impaired Wound Healing, Diabetes Mellitus

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Trial Information

Molecular and Genetic Analysis of Disturbed Wound Healing in Barbadians With Diabetic Foot Ulcers

Diabetes is linked with vascular complications of the eye, kidney and foot. Barbadians
suffer from an unusually high prevalence of diabetic foot complications, which can cause
difficult-to-heal foot ulcers and even lead to amputations of the toes or feet.Studies from
the CDRC have indicated alarmingly high rates of amputation and mortality due to diabetic
foot in Barbados. The goal of this study is to improve early detection of persons at risk of
the vascular complications of diabetes through non-invasive scanning and genetic
susceptibility tests.

The general hypothesis to be tested in this study is that persons with diabetes (PWD) and
non-healing foot ulcers are more likely to have a disturbed mechanism for wound-healing than
PWD without this particular complication. If the hypothesis is proven correct, this will
empower patients and physicians with the diagnostic tests to make early interventions
towards avoiding the complications of diabetes.

Inclusion Criteria:

- clinical diagnosis of diabetes

- Barbadian national

- self reported ethnicity of Black/African descent

- clear knowledge of ulcer history

Exclusion Criteria:

- no clinical diagnosis of diabetes

- non-national of Barbados

- self reported ethnicity not Black/African Descent

- unclear knowledge of ulcer history

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

Genetic Phenotyping (Haptoglobin and TRAPS)

Outcome Time Frame:

18 months

Safety Issue:


Principal Investigator

Robert C Landis, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of the West Indies


Barbados: Ministry of Health

Study ID:




Start Date:

December 2009

Completion Date:

June 2012

Related Keywords:

  • Impaired Wound Healing
  • Diabetes Mellitus
  • Diabetes
  • vascular
  • haptoglobin
  • tumor
  • necrosis
  • factor
  • alpha
  • traps
  • impaired
  • wound
  • healing
  • Impaired wound healing in patients with diabetes mellitus
  • Diabetes Mellitus