Inclusion Criteria:

- Patients with histologically confirmed osteosarcoma, who have no evidence of
metastasis

- At least one measurable lesion

- Life expectancy > 3 months

- ECOG performance status 0-2

- Adequate hematologic, cardiac, renal, and hepatic function

- Patients with prior chemotherapy should have at least 4 weeks clearance period before
entering this study

Exclusion Criteria:

- Evidence of metastasis

- Serious infection

- Evidence of bleeding diathesis

- Significant cardiovascular disease

- Pregnant or lactating woman

- Allergic to E.coli preparation