Adaptive - Predictive Planning for Hypofractionated Bladder Radiotherapy
This study integrates a novel adaptive planning methodology, Adaptive-Planning Organ
LOcalisation (A-POLO), with optimised margins and cone beam CT technology for improving the
accuracy of radiotherapy treatment delivery.
The previous study (CCR2873, REC 07/Q0801/13) evaluated the use of cone beam CT in
radiotherapy for bladder cancer. A larger than expected number of bladder radiotherapy
treatments were seen to have been delivered with some element of geographic miss. Using the
novel adaptive planning method these fractions of radiotherapy could have been correctly
treated. The feasibility of this method has been proven in the previous study, particularly
it has been shown that this method is appropriate and provides a simple solution to the
problem. It can be carried out by the radiographers at the treatment unit without adding
extra time to the treatment.
Intervention Model: Single Group Assignment, Primary Purpose: Treatment
Assessment performed online at the treatment unit & verified offline by additional observer. Primary endpoint is met if there is greater than 75% concordance between the assessment made online & offline.
Dr Robert Huddart
Royal Marsden NHS Foundation Trust
United Kingdom: Research Ethics Committee